ATTENTION DISORDERS AS ASSESSED BY EVENT-RELATED BRAIN POTENTIALS

本项目的目的是研究脑事件的作用- 相关电位，以及精神和神经系统的预后 紊乱 主要强调疾病的诊断特异性 注意力和认知以及识别 或信息处理的阶段，这些阶段是观察到的 性能 同时记录脑事件相关电位， 认知任务的表现被用来区分 注意机制的功能障碍， 精神分裂症，癫痫，季节性情感障碍，饮食失调， 诵读困难，闭合性脑损伤，注意力缺陷多动障碍， 和妥瑞氏症 该项目的一个相关目标是 区分这些疾病的状态与特质属性， 增加对病因的了解。 脑事件相关 电位也被用来研究改变的神经化学物质的作用， 通过比较药物诱导的电生理和行为机制， 与在各种疾病中看到的效果。 之间的相关性 脑事件相关电位和神经成像（磁共振 成像）数据被用来研究指数之间的关系， 信息处理和涉及的大脑区域的体积 精神分裂症的病理生理学 心理相关因素包括 通过将数据与广泛的神经心理学相关联进行调查， 精神和人格的措施，以及性能 行为任务

The aim of this project is to investigate the roles of brain event- related potential, and prognosis of psychiatric and neurological disorders. Major emphasis is on the diagnostic specificity of disorders of attention and cognition and the identification of the specific aspects or stages of information processing underlying observed decrements in performance. Concurrently recorded brain event-related potentials and performance on cognitive tasks are used to differentiate patterns of dysfunction in attentive mechanism in subjects with diagnoses of schizophrenia, seizures, seasonal affective disorder, eating disorders, dyslexia, closed head injury, attention deficit hyperactivity disorder, and Tourette's disorder. A related objective of this project is to differentiate state versus trait attributes of these disorders to increase understanding of their etiologies. Brain event-related potentials are also used to investigate the role of altered neurochemical mechanisms by comparing drug-induced eletrophysiological and behavioral effects with those seen in the various disorder. Correlations between brain event-related potentials and neuroimaging(magnetic resonance imaging) data are used to study the relationship between indices of information processing and the volume of brain regions implicated in the pathophysiology of schizophrenia. Psychological correlates are investigated by relating the data to extensive neuropsychological, psychiatric, and personality measures as well as to performance on behavioral tasks.