ALUMINUM STANDARDS FOR ALZHEIMER'S DISEASE RESEARCH

铝（Al）在土壤中的浓度和分布数据 各实验室报告的阿尔茨海默病（AD）标本 很难比较，原因有几个，包括不同的 微量分析技术，样品制备程序， 伪影和检测极限。 基本信息 需要解释和定量比较数据（图像数据 尤其是）在许多已发表的结果中缺乏。 样品 没有按照一致的疾病标准选择人群， 定义. 结果，不仅无法澄清 铝在疾病病因中的作用，但它一直是 甚至不可能确定在何种条件下它可能有一个 作用 要开始解决数据比较的问题，需要两个步骤 已采取：铝掺杂的脑匀浆进行了研究 作为潜在的多技术标准，以及一个关于 铝生物标准已组织的研讨会上， 铝毒性研究问题（温哥华，1995年7月8日） 提出一个共同的标准和可接受的实验程序， AD中使用的各种分析技术。 描述的结果 问题组总结中包含了以下内容，其中提出了Al掺杂 脑匀浆作为多元素标准品。

Data on the concentrations and distributions of aluminum (Al) in Alzheimer's disease (AD) specimens reported by various laboratories are difficult to compare for several reasons, including different microanalytical techniques, specimen preparation procedures, artifacts, and detection limits. The fundamental information necessary to interpret and to quantitatively compare data (image data in particular) has been lacking in many published results. Sample populations have not been selected to a consistent standard of disease definition. As a result, not only has it been impossible to clarify the role of Al in the etiology of the disease, but it has been impossible even to determine the conditions under which it may have a role. To begin to address the problem of data comparison, two steps have been taken: Al- doped brain homogenates have been investigated as potential multitechnique standards, and a special Issue Group on Aluminum Biological Standards has been organized for the Workshop on Research Issues in Aluminum Toxicity (Vancouver, July 8, 1995) to propose a common standard and acceptible experimental procedures for the various analytical techniques used in AD. The results described here are included in the Issue Group Summary, which proposes Al-doped brain homogenates as the multielement standard.