Centre for Genomic Research: Genomics Hub Renewal

在过去的5年里，新的测序技术的应用改变了分子生物学。这些技术使DNA和RNA的测序速度比以前可能的要快得多，而且成本大大降低。这些进展为在MRC职权范围内工作的研究人员创造了机会。因此，MRC在2009年为四个测序中心提供了资金，以承认这一点，其中之一是利物浦基因组研究中心(CGR)。CGR有许多不同的收入来源。它通过其生物分子分析设施接受MRC和自然与环境研究理事会(NERC)的资助，为在各自职权范围内工作的团体提供协作服务。该设施还受益于利物浦大学在工作人员工资和设备采购方面的支持。CGR还通过从学术合作者或商业客户那里重新收取项目成本来产生收入。此外，CGR联席主任拥有许多赠款，因此CGR既是研究实验室，也是服务实验室。我们将在未来三年通过向合作者和客户收取全部成本，使CGR的服务运营在财务上自给自足。这项申请寻求再资助两年，但费率将大幅降低，以完成CGR向财务自给自足的过渡。为了实现这一演变，CGR将继续其目前的工作，但也将实施一些新的举措1。我们将扩大和发展CGR的设备，以跟上吞吐量和成本的进步。2.我们将通过聘请业务经理来专注于扩大我们的市场覆盖范围。我们将举办一些针对MRC研究界的培训活动，让生物医学研究人员了解基因组技术、分析方法和高通量测序数据的应用。为了扩大我们在MRC研究社区的影响力，我们将提供第二次泵启动竞赛，允许与MRC相关的申请者以最低的成本在CGR设施内进行试验或技术开发项目。

Over the last 5 years molecular biology has been transformed by the application of new sequencing technologies. These technologies allow DNA and RNA to be sequenced much faster than was previously possible and at a significantly reduced cost. These developments create opportunities for researchers working within the MRC remit. Hence, the MRC funded four sequencing hubs in recognition of this in 2009, one of which is the Liverpool Centre for Genomic Research (CGR).The CGR has a number of different income streams. It receives funding from the MRC and the Natural and Environmental Research Council (NERC), via its Biomolecular Analysis Facility, to provide collaborative services to groups working within the respective remits. The facility has also benefited from support by the University of Liverpool for staff salaries and equipment purchases. The CGR also as generates income by re-charging project costs from academic collaborators or commercial clients. In addition, the CGR co-directors hold a number of grants and hence the CGR is both a research lab and a service lab. We will make the service operation of the CGR become financially self-sustaining over the next 3 years by recharging the full cost to collaborators and clients.This application seeks funding for a further two years but at a substantially reduced rate that will complete the transition of the CGR to financial self-sustainability. To enable this evolution, the CGR will continue its current work but also put in place a number of new initiatives.1. We will expand and develop the equipment in the CGR to keep up with advances in throughput and cost. 2. We will focus on expanding our market reach by hiring a Business Manager.3. We will present a number of training events aimed at the MRC research community to inform biomedical researchers on genomic technologies, analytical methods and applications of high-throughput sequencing data.4. To expand our reach into the MRC research community we will offer a second pump-priming competition to allow MRC-linked applicants to undertake trial or technology development projects within the CGR facility at minimal cost.