TRAINING PROGRAM IN MOLECULAR AND VIRAL ONCOLOGY

描述(申请者描述)：该计划的目标是提供高质量的博士后和博士后培训，并为分子和病毒肿瘤学的研究和教学工作中的杰出个人做好准备。申请者已经建立了一个多学科、多部门、由17名调查人员组成的小组，他们在这些领域具有公认的专业知识和研究兴趣。这些教师正在进行的研究项目包括：致癌RNA和DNA病毒的遗传学和复制的研究，免疫反应各组成部分的成熟和发育研究，以及在肿瘤发生过程中发生的异常，通过DNA结构和调控元件的研究调节基因表达，癌基因在癌症发生中的作用，以及宿主免疫反应的分子研究。这项建议中的教职员工所在的实验室设备齐全，资金充足，可用于研究的所有阶段。参与的教职员工认为，这代表着在分子和病毒肿瘤学领域提供出色的博士前和博士后培训的良好环境。博士前实习生必须达到一个名为“细胞和分子生物学(CMB)研究生项目”的创新多部门项目的入学和毕业标准，或一个高度选择性的医学博士/博士项目。注册分子和病毒肿瘤学课程的学生的具体要求包括参加病毒和分子肿瘤学的高级课程以及期刊俱乐部和参加与该学科各方面相关的研讨会。博士后实习生还将参加精选课程、期刊俱乐部、研讨会和讨论小组。除了研究活动和课程外，培训计划还包括参加地方、地区和国家科学会议。博士后和博士后实习生的招聘将通过各种招聘方案在国家一级进行，并将鼓励招募少数民族参与者。

DESCRIPTION (Applicant's Description): The objective of this program is to provide high quality training at the predoctoral and postdoctoral levels and to prepare outstanding individuals for careers in research and teaching in Molecular and Viral Oncology. The applicants have developed a multidisciplinary, multi-departmental, group of seventeen investigators with proven expertise and research interests in these areas. The ongoing research programs of these faculty members include the investigation of the genetics and replication of oncogenic RNA and DNA viruses, studies on the maturation and development of various components of the immune response and aberrations that occur during oncogenesis in this system, regulation of gene expression through studies on DNA structure and regulatory elements, the role of oncogenes in carcinogenesis and molecular studies of the host immune response. The faculty members in this proposal occupy laboratories that are well-equipped and well-funded for all phases of the research. The participating faculty believes that this represents an excellent environment for providing outstanding predoctoral and postdoctoral training in the area of Molecular and Viral Oncology. Predoctoral trainees are required to meet the admission and graduation standards of an innovative multi- departmental program entitled the "Cellular and Molecular Biology (CMB) Graduate Program" or a highly selective M.D./Ph.D. program. Specific requirements for students enrolled in the Molecular and Viral Oncology Program include participation in an advanced level course in viral and molecular oncology as well as journal clubs and attendance at seminars relevant to the various aspects of this discipline. Selected course offerings, journal clubs, seminars, and discussion groups will be attended by postdoctoral trainees also. In addition to research activities and courses the training program includes participation in local, regional and national scientific meetings. Recruitment of both predoctoral and postdoctoral trainees will be at the national level through a variety of recruitment programs and will encourage recruitment of minority participants.