Development of small molecule IRAP inhibitors for treating memory deficits

我们已经根据它们抑制蛋白质催化活性的能力鉴定了一系列小分子化合物，使用IRAP的计算机模型筛选化学文库。本研究计划旨在研究这些化合物的性质及其治疗阿尔茨海默氏痴呆症的能力。在这个项目结束时，我们将有2个先导化合物家族适合开发成为治疗阿尔茨海默病的新一类治疗剂。

We have identified a series of small molecule compounds based on their ability to inhibit the catalytic activity of a protein, IRAP using a computer model of IRAP to screen chemical libraries. This research proposal aims to investigate the properties of these compounds and their ability to treat Alzheimer's dementia. At the conclusion of this project, we will have 2 families of lead compounds suitable for development into a new class of therapeutic agents for treating Alzheimer's disease.