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FOURTEEN DAY ORAL RANGEFINDING STUDY IN RATS AND DOGS AN

FOURTEEN DAY ORAL RANGEFINDING STUDY IN RATS AND DOGS AN
大鼠和狗十四天口腔测距研究
批准号：
6153044
负责人：
BARRY S LEVINE
金额：
$49.47万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
未结题
起止时间：
1999-09-30 至
来源：
https://reporter.nih.gov/project-details/6153044
关键词：
behavior test clinical chemistry cytochrome P450 dogs dosage drug adverse effect drug screening /evaluation histology laboratory rat oral administration ribonucleotide reductase stilbenes toxicology

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中文摘要
翻译
将在大鼠和犬中进行为期14天的口服剂量范围探索研究，以确定白藜芦醇的剂量限制毒性。终点将包括行为评估、食物和水消耗以及临床和解剖病理学。然后在大鼠和犬中进行28天重复经口给药研究。 终点将包括摄食量和饮水量、体重、临床观察、心脏和眼科评估、临床化学和血液学、血浆检测试剂水平、尿液分析以及解剖学和组织学病理学。将进行细胞色素P450同工酶和2相酶调节的生化评价。 将确定剂量相关毒性。
英文摘要
A 14-day, oral rangefinding study will be conducted in rats and dogs to identify the dose limiting toxicities of resveratrol. Endpoints will include behavioral assessment, food & water consumption, and clinical and anatomical pathology. Twenty-eight day, repeat-dose, oral studies will then be conducted in rats and dogs. Endpoints will include food and water consumption, body weight, clinical observation, cardiac and ophthalmic assessment, clinical chemistry and hematology, plasma test agent levels, urinalysis, and anatomic and histologic pathology. Biochemical evaluation of cytochrome P450 isoenzyme and phase 2 enzyme modulation will be conducted. Dose associated toxicities will be identified.
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FOURTEEN DAY ORAL RANGEFINDING STUDIES AND TWENTY-EIGHT
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FOURTEEN DAY ORAL RANGEFINDING STUDY IN RATS AND DOGS AN
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