EFFECTIVENESS OF GRANULOCYTE TRANSFUSIONS

临床试验结果显示， 或者真菌感染是有争议的一些研究发现 粒细胞输注对治疗细菌感染有效 但其他几个还没有。虽然粒细胞输注一直是 有效地治疗真菌感染的贫血动物模型， 在治疗人类方面并不有效。的无效性 粒细胞输注可能部分是由于 可以收集的粒细胞。最近的研究表明， 收集的粒细胞数量可以增加2至5倍， 给予供体粒细胞结肠刺激因子（G-CSF）。G-CSF 动员的粒细胞输注可有效治疗细菌性 和真菌感染。本研究旨在 以确定是否有严重的血小板减少性再生障碍性贫血患者 细菌或真菌感染可从粒细胞输注中获益。 合格的患者将被随机分配接受常规 抗菌治疗或G-CSF动员的粒细胞输注加 常规抗菌治疗。它们的感染对 将监测治疗以及它们的存活。

The results of clinical trials to treat neutropenic adults with bacterial or fungal infections are controversial. Some studies have found that granulocyte transfusions are effective in treating bacterial infections but several other have not. While granulocyte transfusions have been effective in treating fungal infections in neutropenic animal models, they have not been effective in treating humans. The ineffectiveness of granulocyte transfusions is likely due in part to the limited quantity of granulocytes that can be collected. Recently, it has been shown that the number of granulocytes collected can be increased two to five-fold by giving donors granulocyte colon-stimulating factor (G-CSF). G-CSF mobilized granulocyte transfusions may be effective in treating bacterial and fungal infections in neutropenic adults. The purpose of this study is to determine if severely neutropenic aplastic anemia patients with bacterial or fungal infections benefit from granulocyte transfusions. Eligible patients will be randomly assigned to either receive conventional antimicrobial therapy or G-CSF mobilized granulocyte transfusions plus conventional antimicrobial therapy. The response of their infection to the treatments as well as their survival will be monitored.