EFFECT OF DIETARY RESTRICTION ON BONE MINERAL CONTENT OF RHESUS MONKEYS

目的评价限食与衰老的关系 对恒河猴骨代谢的影响 结果骨密度降低 然而，在饮食受限的动物中，这反映了较小的体型 而不是病理性骨质减少。 此外，饮食限制可能 防止脊柱骨关节炎的发展。 讨论 年龄相关性骨丢失的发病机制尚不清楚。 作为膳食 限制（DR）延缓衰老的许多方面，它也可能改变 骨骼变化 这项研究的目的是检查 中度DR的影响（减少30%的热量摄入， 个体基线值）。 骨量（双能X线 骨吸收测定法）、骨转换（骨钙素、ICTP和NTx）和腰椎 脊柱骨关节炎（OA; X线片）进行了纵向检查， 雄性（15只对照[C]，15只限制[R]; DR 96个月后）恒河猴 8-14岁的猕猴在DR发作时的全身骨量 与C组的男性和女性相比，R组较低。 在雌性中，R 后-前脊柱的骨量也低于C， 桡骨（桡骨远端骨矿物质含量除外）。 血清 周转标志物，钙和磷浓度没有 C和R的区别。 此外，睾酮和FSH 在男性中没有变化。 有较少的证据表明， R男性。 我们认为较低的骨量反映了较小的身体 大小，而不是病理性骨质疏松。 在此模型中，DR不 引起有害的内分泌影响，并可能提供保护， 脊柱OA。 未来的方向我们计划继续使用DXA， X光片和骨代谢标志物，以更好地表征 恒河猴的骨骼老化过程，使它们变得更好， 了解骨质疏松症研究的模型。 关键词骨质疏松症， 骨密度，衰老，骨代谢，DXA基金NIH PO 1 AG 11915

OBJECTIVE To assess the effect of dietary restriction and aging upon bone metabolism in rhesus monkeys. RESULTS Bone mass was lower in dietary restricted animals, however this reflects smaller body size and not pathological osteopenia. In addition, dietary restriction may protect against the development of spinal osteoarthritis. DISCUSSION The pathogenesis of age-related bone loss is unclear. As dietary restriction (DR) retards many aspects of aging, it may also alter skeletal changes. The purpose of this study was to examine the effects of moderate DR (30% reduction in caloric intake from individual baseline values) on bone. Bone mass (dual-energy X-ray absorptiometry), turnover (osteocalcin, ICTP, and NTx) and lumbar spine osteoarthritis (OA; radiographs) were examined longitudinally in male (15 Control [C], 15 Restricted [R]; after 96 months of DR) rhesus macaques 8-14 years of age at the onset of DR. Total body bone mass was lower in R compared to C males and females. In the females, R bone mass was also lower than C at the posterior-anterior spine and radius (except for distal radius bone mineral content). Serum turnover markers, and calcium and phosphorus concentration were not different between C and R groups. In addition, testosterone and FSH in the males were unchanged. There was less evidence of spi nal OA in R males. We believe the lower bone mass reflects the smaller body size, and not pathological osteopenia. In this model, DR does not cause deleterious endocrine effects and may afford protection against spinal OA. FUTURE DIRECTIONS We plan to continue using DXA, radiographs and markers of bone metabolism to better characterize the skeletal aging process in rhesus monkeys, making them better understood models for osteoporosis research. KEY WORDS osteoporosis, bone density, aging, bone metabolism, DXA FUNDING NIH PO1 AG11915