BIOACTIVITY & NUTRITIONAL QUALITY OF MILK PROTEIN FRACTIONS

从流行病学的角度来看，母乳喂养的婴儿 感染和感染的持续时间较短。 这些差异 可能是由于母乳和 公式 糖巨肽（GMP，一种高度负电荷的 牛奶中的碳水化合物）可能会模仿细菌使用的聚糖 从而可以抑制附着 和定殖，从而防止感染。 α-乳白蛋白， (ALA，一种主要的牛奶蛋白）被认为是一种主要的 对母乳喂养婴儿平衡血浆氨基酸模式的贡献 婴儿和可能有助于吸收钙和锌。 的 GMP或ALA补充剂的效果将通过以下能力进行评估： 以应对微生物的挑战，以及通过追踪矿物质， 氨基状态 目的研究糖巨肽对糖尿病的作用 (GMP)和α-乳白蛋白（ALA）对致病性 细菌以及人体测量学、血液学和矿物质指标 幼猴的营养状况。 结果虽然在 长度进行了观察，体重之间的显着差异 GMP和ALA的动物喂养和母乳喂养的婴儿被发现。 血清锌水平显著升高，分别为2、3、4和5 月龄。 动物对锌的吸收率较高 与母乳喂养的婴儿相比，接受ALA或GMP。 虽然 胸腺大小、接受ALA或 母乳对接种E.杆菌作为 通过分类白色血细胞计数的变化进行评估。 未来 为了评估其他乳蛋白组分对乳蛋白的影响， 各种病原体。 关键词糖巨肽，α-乳白蛋白，E. 大肠杆菌、病原体、益生元、婴儿营养

Significance Epidemiologically, breast-fed infants contract fewer infections and have infections of shorter duration. These differences may be due to differences in composition between breast milk and formula. Glycomacropeptide, (GMP, a highly negatively charged carbohydrate found in milk) may mimic the glycans that bacteria use for attachment in the small intestine and thus may inhibit attachment and colonization, thereby preventing infections. Alpha-lactalbumin, (ALA, a predominant milk protein) is believed to make a major contribution to the balanced plasma amino acid pattern of breast-fed infants and may aid in the absorption of calcium and zinc. The effects of GMP or ALA supplementation will be assessed by the capacity to respond to a microbial challenge as well as by tracing mineral and amino status. Objectives To study the effects of glycomacropeptide (GMP) and alpha-lactalbumin (ALA) on the colonization of pathogenic bacteria as well as anthropometry, hematology and indices of mineral nutriture in infant monkeys. Results Although no differences in length were observed, a significant differences in weight between animals fed GMP and breast-fed infants was found. GMP and ALA resulted in significant increases in serum zinc as 2, 3, 4 and 5 months of age. The absorption of zinc was higher in the animals receiving ALA or GMP as compared with breast-fed infants. Although there were no differences in thymus size, animals receiving ALA or breast milk responded differently to inoculation of E. coli as assessed by changes in differential white blood cell count. Future Directions To evaluate the effect of other milk protein fractions on various pathogens. KEY WORDS glycomacropeptide, alpha-lactalbumin, E. coli, pathogens, prebiotic, infant nutrition FUNDING Private Sector