OBESITY, HYPERTENSION, FATTY ACIDS, AND VASCULAR CONTROL

本研究的目的是：1)确定肥胖高血压患者中脂肪升高的NEFA是否会重现血液动力学异常，包括血压升高、血管张力和神经血管反应性增强以及内皮依赖性血管舒张功能受损。2)确定降低肥胖高血压患者的NEFAs是否会降低血压，降低血管张力和神经血管反应性，并增强内皮依赖性血管舒张。3)确定NEFAs诱导血管平滑肌细胞有丝分裂和增强血管紧张素增殖作用的信号转导机制。4)确定这些相同的NEFAs损害内皮细胞NOS活性和血管组织中内皮依赖性血管舒张的PKC-in依赖机制

The aims of this study: 1)Determine if fat raising NEFA's in lean normotensives reproduce hemodynamic abnormalitites observed in obese hypertensives including elevated BP, enhanced vascular tone and neurovascular reactivity, and impaired endothelium-dependent vasodilation. 2)Determine if lowering NEFAs in obese hypertensives decrease BP, reduce vascular tones and neurovascular reactivity, and enhance endothelium- dependent vasodilation. 3)Determine the signal transduction mechanism(s) by which NEFAs induce mitogenesis and enhance proliferative effects of angiotensin in vascular smooth muscle cells. 4)Identify the PKC-in dependent mechanism(s) by which these same NEFAs impair NOS activity in endothelial cells and endothelium-dependent vasodilation in vascular tissue