COMPARATIVE MEDICINE RESEARCH CENTER

比较医学研究中心的长期目标是 密苏里-哥伦比亚大学兽医病理学系 是为了促进生物医学研究的进步，从而提高 通过提高实验室的质量和定义， 动物通过基础和应用生物医学研究有关， 实验动物医学、病理学和科学。 历史上， 生物医学研究的进展涉及动物。 动物被利用 在NIH资助的所有研究中大约有一半。 通过提高我们 了解生物学，病理生理学，疾病和研究 使用动物'试剂'更有意义的动物外推 衍生数据用于人类健康和疾病将成为可能。 我们的具体 目的包括：1）重点调查，以提供了解， 当代影响使用生物技术的主要问题的可能解决办法 研究中的动物; 2）通过以下方式传播这些信息 适当的出版物和介绍;以及3）协助 应用我们的研究成果。 另一个目的是提供研究 培训机会，并鼓励在广泛领域开展教育， 实验动物科学 我们已经确定了六个影响动物使用的主要问题， 研究，并在本提案中，我们提出了研究项目的设计， 他们在以下项目标题下的研究： --啮齿动物孤儿病原病毒：分子特征和 诊断试剂的发展 --啮齿动物孤儿致病病毒：发病机制和与研究的相互关系 --肠道、分节、丝状细菌的生物学， 啮齿动物 --用于诊断试剂的特异性病毒抗原的生产 使用杆状病毒表达系统 --病毒基因扩增试验检测小鼠病毒， 生物样品 --纤毛相关呼吸道芽孢杆菌感染的发病机制

The long-term objective of the Comparative Medicine Research Center in the Department of Veterinary pathology at University of Missouri-Columbia is to enhance advances in biomedical research and thereby improve the human condition by improving the quality and definition of laboratory animals through basic and applied biomedical research related to laboratory animal medicine, pathology, and science. Historically, progress in biomedical research has involved animals. Animals are used in about half of all research funded by the NIH. By improving our understanding of the biology, pathophysiology, diseases, and research uses of the animal 'reagent' more meaningful extrapolation of animal derived data to human health and disease will be possible. Our specific aims include: 1) focused investigations to provide understanding and possible solutions to major contemporary problems affecting the use of animals in research; 2) dissemination of this information through appropriate publications and presentations; and 3) to assist in the application of our research findings. Another aim is to provide research training opportunities and to encourage education in the broad area of laboratory animal science. We have identified six major problems that affect the use of animals in research and in this proposal we present designs of research projects for their study under the following project titles: -- Rodent Orphan Pathoviruses: Molecular Characterization and Development of Diagnostic Reagents -- Rodent Orphan Pathoviruses: Pathogenesis and Interface with Research -- The biology of the Intestinal, Segmented, Filamentous Bacteria of Rodents -- Production of Specific Viral Antigens for Use as Diagnostic Reagents Using a Baculovirus Expression System -- Viral Gene Amplification Assays of detection of Murine Viruses in Biological Samples --Pathogenesis of Cilia-Associated Respiratory Bacillus Infection