FLYBASE: A DROSOPHILA RELATIONAL DATABASE

果蝇，果蝇黑腹果蝇，是最好的模型之一 生物体为现代生物学研究的多个方面。这个 除了其他优势外，这只苍蝇拥有无与伦比的遗传工具， 使黑腹蛇成为一种无价的研究系统，因此它 被选为获得密集基因组的模式系统之一 分析是人类基因组计划的一部分。为了支持这一点 经过努力，我们发起了一个项目，为基因组和果蝇提供 在一项研究中获得一组核心遗传信息的社区 我们称之为FlyBase数据库的资源。有这么多的信息 在果蝇身上，它不能被任何一个人抓住；这 对田间生产率产生负面影响。核心的可用性 果蝇数据库是一种必要且经济高效的工具，可以最大限度地提高 研究界的生产力。FlyBase最初的资金来源是 一个3年的原型，这项提案是为了续签资金作为一个完整的- 成熟的生产数据库。FlyBase信息通过Active获取 并及时精选文献，从解析和批量加载 来自以前的目录和数据库以及来自批量的信息 基因组计划的贡献，特别是伯克利果蝇 基因组计划(BDGP；Pi，G.Rubin)与欧洲果蝇基因组 项目(EDGP；PI，F.Kafatos)。数据存储在中央数据库中 关系数据库，为数据模型配置，提供许多 果蝇的强健表现所需的相互关系 基因组。这些数据可以在IUBio上以电子方式获得 (ftp.Bio.Indiana，EDU)通过各种网络协议，包括 Gopher+、WWW、WAIS和FTP。数据的硬拷贝摘录如下所示 果蝇信息服务(DIS)特刊。一个FlyBase- BDGP Collaboration将开发集成的图形用户界面，以 使用ACeDB软件的所有FlyBase和BDGP数据。由此产生的 产品《果蝇百科全书》将有几个版本 网络模式和与Macintosh兼容的CD-ROM。FlyBase成员将 继续与其他小组合作，提供FlyBase和 其他基因组数据库，并将FlyBase整合到其他前端。 使用这些不同的电子访问模式，FlyBase为用户提供 具有强大的查询和浏览工具，可恢复相关 信息。将继续实施用于用户输入的机制 设计、管理和编辑工作，并面向广大用户 支持。

The fruit fly, Drosophila melanogaster, is one of the premier model organisms for many aspects of modern biological research. The unparalleled genetic tools available in this fly, among other advantages, have made D. melanogaster an invaluable research system, and hence it has been selected as one of the model systems to receive intensive genomic analysis as part of the human genome initiative. In support of that effort, we initiated a project to provide the genomic and Drosophila communities with access to a core set of genetic information in a Research Resource that we call the FlyBase database. There is so much information on Drosophila that it cannot be grasped by any one individual; this negatively affects productivity in the field. The availability of a core Drosophila database is a necessary and cost-effective tool to maximize the productivity of the research community. FlyBase was originally funded as a 3 year prototype, and this proposal is for renewed funding as a full- fledged production database. FlyBase information is obtained by active and timely curation of the literature, from parsing and bulk-loading of information from previous catalogs and databases, and from bulk contributions from genome projects, particularly the Berkeley Drosophila Genome Project (BDGP; PI, G. Rubin) and the European Drosophila Genome Project (EDGP; PI, F. Kafatos). The data are stored in a central relational database, configured for a data model that provides the many interrelationships necessary for a robust representation of the Drosophila genome. The data are available electronically at IUBio (ftp.bio.indiana,edu) through a variety of network protocols, including Gopher+, WWW, WAIS and FTP. Hardcopy excerpts of the data are produced as special issues of the Drosophila Information Service (DIS). A FlyBase- BDGP collaboration will develop an integrated graphical user interface to all FlyBase and BDGP data using the ACeDB software. The resulting product, the Encyclopedia of Drosophila, will be available in several network modes and by Macintosh-compatible CD-ROMs. FlyBase members will continue to work with other groups to provide merged views of FlyBase and other genomic databases and to integrate FlyBase into other front ends. Using these various modes of electronic access, FlyBase provides users with powerful query and browsing tools for recovering relevant information. Mechanisms will continue to be implemented for user input in the design, curation and editing efforts, and for substantial user support.