DIABETES PREVENTION TRIAL-TYPE 1 DIABETES (DPT-1)

这项多中心随机试验旨在评估 低剂量胰岛素治疗，与周期性持续 胰岛素输注（“β细胞静息”），以延迟和/或预防 胰岛素依赖型糖尿病的一级亲属 患有IDDM的人。 非糖尿病，胰岛细胞抗体阳性 胰岛素分泌第一时相也有改变的个体 符合随机化要求。去年，大约 100个胰岛素依赖型糖尿病家庭参加了以前的研究， 与糖尿病遗传学专家进行了联系，并了解了DPT-1试验的情况。 对一些感兴趣的家庭成员进行了抗体筛查， 未发现伊卡+个体。 征聘工作将继续在 来年

This multicenter randomized trial is designed to evaluate the ability of low dose insulin therapy, in association with periodic continuous insulin infusions ('beta cell rest') to delay and/or prevent the development of insulin dependent diabetes in first degree relatives of individuals with IDDM. Nondiabetic, islet cell antibody positive individuals who also have alterations in first phase insulin secretion are qualified for randomization. During the previous year, approximately 100 IDDM families who had participated in previous studies of the genetics of diabetes were contacted and informed about the DPT-1 trial. Antibody screening of some interested family members was performed but no ICA+ individuals were identified. Recruitment will continue in the coming year.