TURNOVER AND OXIDATION OF LEG INTRACELLULAR FATTY ACID POOLS

本提案的目标是确定FFA的主要决定因素 通量和检查肝脏和肌肉FFA代谢。 这项研究在推迟了几年之后现在重新开始，以开发新的 测量肌内脂肪酸代谢的方法。 我们增加了 稳定同位素的研究，以使分配 脂肪酸转化为肌内甘油三酯，非酯化脂肪酸 酸和长链酰基肉毒碱。 我们不再将股动脉 动脉或股静脉导管作为本研究的一部分。 的积极 本方案中初步研究的结果作为 竞争更新NIH补助金的基础， 执行。

Objectives of this proposal are to define the major determinants of FFA flux and examine liver and muscle FFA metabolism. This study is now resuming after a several year delay to develop new methods to measure intramuscular fatty acid metabolism. We have added stable isotopes to this study in order to allow the partitioning of fatty acids into intramuscular triglycerides, non-esterified fatty acids, and long-chain acylcarnitines. We are no longer placing femoral artery or femoral vein catheters as part of this study. The positive results from the preliminary studies in this protocol served as the basis for competing renewal for the NIH grant under which this is performed.