PROTON MRS OF PATS W/ AIDS DEMENTIA COMPLEX: MULTICENTER ACTG 301 DRUG EVAL

这项研究是关于艾滋病患者的 痴呆综合症患者参加了一个双盲， 美金刚作为治疗这种疾病的安慰剂对照研究 disorder. 目的是检查大脑的模式和程度， 使用质子磁共振波谱非侵入性损伤 （MRS）。 宾夕法尼亚大学是参与这项研究的11个中心之一。 联合治疗研究和MRS研究工作。 该项目采用 FDA批准的MRS方法称为PROBE， 获取和分析质子光谱的自动化方法。 我们选择 来自基底神经节（深部灰质）的体素（8 cc），中线 后顶叶（灰质）和中额叶 半卵圆中心（白色物质）。 目前，已有12名患者 接受神经心理学测试以及MRS方案之前， 药物/安慰剂治疗。 MRS方案已在9个国家重复 这些患者在治疗16周后。 的 PROBE方法仅报告三种代谢物的水平， NAA、Cho和mI与Cr的比值。我们在发展常规， 在时间域中拟合，这将允许我们确定那些 所有代谢物的共振区域， 特别是大分子蛋白质中的氨基酸。 这项研究将 可能揭示了与艾滋病相关的大脑代谢 异常，细胞损伤和神经行为模式， 艾滋病痴呆综合症。 这项工作也应该肯定的适用性 质子磁共振波谱的研究，非侵入性和在体内， 艾滋病病毒感染者的大脑中发生的事件。 最后，通过这样的 我们可以衡量新的中枢神经系统治疗的有效性。

This study concerns itself with patients suffering from the AIDS dementia complex who were enrolled in a double-blind, placebo-controlled study of memantine as a treatment for this disorder. The aim is to examine the pattern and extent of cerebral injury noninvasively using proton magnetic resonance spectroscopy (MRS). The University of PA is one of eleven centers involved in this combined treatment study and MRS research effort. The project uses the FDA-approved method of MRS referred to as PROBE, which is an automated method of acquiring and analyzing proton spectra. We select voxels (8 cc) from the basal ganglia (deep gray matter), the midline of the posterior parietal lobes (gray matter) and the mid-frontal centrum semiovale (white matter). Currently, twelve patients have undergone neuropsychological testing as well as the MRS protocol prior to drug/placebo treatment. The MRS protocol has been repeated in nine of these patients after sixteen weeks of therapy. The PROBE method only reports on the levels of three metabolites, giving the ratios of NAA, Cho, and mI to Cr. We are developing routines, fitting within the time domain, that will permit us to determine those areas of resonance which are attributable to all metabolites, especially the amino acids in macromolecule proteins. The study will likely reveal relationships between HIV-associated brain metabolic abnormalities, cellular injury and the neurobehavioral patterns of the AIDS dementia complex. This work should also affirm the suitability of proton MRS to studying, noninvasively and in vivo, the pathogenetic events in brains of patients infected with HIV. Finally, through such work we can gauge the effectiveness of novel CNS therapies.