HIGH RESOLUTION PROTON MR SPECTROSCOPY OF HIV INFECTED PATIENTS

我们利用高分辨率质子磁共振 光谱学在我们对HIV感染者的研究中。 由于神经元 损害发生在疾病的中期或晚期，我们的 目的是确定MRS是否可以检测代谢 早期阶段的变化。 我们还检查了 艾滋病痴呆综合征（ADC 1）的中期阶段。 为了 获得皮质灰质的“纯”光谱，并选择白色 在物质区域，我们采用了一维方法的MRS成像 利用化学位移。 在过去的一年里，我们检查了29个症状 和无症状患者以及6名健康对照。 MRS数据 显示了患者和正常人之间的两个明显差异 对照 ADC患者组显示出显著较低的 灰质中NAA/Cr比值均高于两对照组 无ADC组。 最后一组是 其特征在于在白色材料中具有较高的mI与Cr的比率， 灰色和白色物质中的NAA/Cr与 对照组 这些结果表明，高分辨率MRS将 确实有助于额叶代谢的评估， 大脑新陈代谢的变化。 作为艾滋病临床试验的一部分 组，我们也使用这种方法来评估患者参加 该研究涉及ACTG-301，美金刚NMDA受体拮抗剂。

We have made use of high resolution, proton Magnetic Resonance Spectroscopy in our study of HIV-infected patients. Since neuronal damage occurs in the intermediate or late stages of the disease, our objective was to determine whether MRS could detect metabolic alterations in the early stages. We also examined patients in the intermediate stages of AIDS Dementia Complex (ADC 1). In order to obtain "pure" spectra of cortical gray matter and selected white matter regions, we employed a one-dimensional method of MRS imaging using chemical shift. This past year we have examined 29 symptomatic and asymptomatic patients as well as six healthy controls. MRS data showed two distinct differences between the patients and normal controls. The group of patients with ADC showed a significantly lower ratio of NAA to Cr in gray matter than those of both the control group and the group of patients without ADC. This last group was characterized by a higher ratio of mI to Cr in white mat ter and a similar NAA/Cr in both gray and white matter as compared to the control group. These results suggest that high resolution MRS will indeed aid in the evaluation of frontal lobe metabolism by identifying changes in brain metabolism. As part of the AIDS Clinical Trials Group, we are also using this method to evaluate patients enrolled in the study involving the ACTG-301, memantine NMDA receptor antagonist.