HUMAN HEALTH EFFECTS OF EXPOSURE TO ORGANOCHLORINE COMPOUNDS

持久性卤化有机污染物（如滴滴涕、多氯联苯、二恶英）在公共卫生方面需要特别关注，因为它们在生态系统中无处不在，并可能通过饮食在本底接触水平上对人类健康造成不利影响。我们正在就本底接触有机氯对人体健康的影响进行几项研究。我们已经完成了一项关于洛杉矶非裔美国妇女血清p、p- dde（滴滴涕的代谢物）和多氯联苯水平与乳腺癌风险关系的病例对照研究的实地工作。已经登记了300个病例和300个对照，并将编制数据以供1999年分析。我们的主要项目是调查围产期合作项目参与者在子宫内接触有机氯残留物对健康的影响，为他们提供标本库（母亲血清）。正在研究的关联是：1)母亲的p、p-DDE水平与男性后代尿道下裂、隐睾和多毛症的风险有关；2)母亲的PCB水平与儿童神经发育结果、听力和智商有关；3)母亲的DDE水平与男性后代青春期身体习惯有关。我们还在北卡罗来纳州早期有机氯暴露影响队列研究（Rogan/Gladen研究）中研究子宫内多氯联苯暴露与新生儿甲状腺功能的关系，并与空军健康研究的研究人员合作，研究二恶英暴露对健康的影响。-多氯联苯，DDE，隐睾，尿道下裂，乳腺肿瘤，神经发育，智商，甲状腺-人类受试者

Persistent halogenated organic pollutants (e.g., DDT, PCBs [polychlorinated biphenyls], dioxin) command special attention in public health because they are ubiquitous in the ecosystem and may be causing adverse human health effects at background levels of exposure, via diet. We are conducting several studies of the human health effects of background exposure to organochlorines. We have completed field work on a case-control study of serum p,p-DDE (a metabolite of DDT) and PCB levels in relation to risk of breast cancer among African-American women in Los Angeles. Three hundred cases and 300 controls have been enrolled, and the data will be prepared for analysis in 1999. Our main project is an investigation of health effects of in utero exposure to organochlorine residues among participants in the Collaborative Perinatal Project, for whom a specimen bank (mothers serum) is available. Associations being examined are: 1) mothers p,p-DDE levels in relation to risk of hypospadias, cryptorchidism, and polythelia in male offspring, 2) mothers PCB level in relation to childs neurodevelopmental outcomes, hearing, and IQ, 3) mothers DDE level in relation to body habitus in adolescence in male offspring. We are also examining in utero PCB exposure in relation to neonatal thryoid function in the North Carolina cohort study of effects of early-life organochlorine exposure (Rogan/Gladen study), and are collaborating with investigators from the Air Force Health Study to examine health effects of dioxin exposure. - PCBs, DDE, Cryptorchidism, Hypospadias, Breast neoplasms, Neurodevelopment, IQ, Thyroid - Human Subjects