STUDY OF SOCIAL AND COGNITIVE ASPECTS OF SCHIZOPHRENICS

该项目使用实验心理学技术来研究精神分裂症患者在眼运动、认知和社会任务方面的缺陷是否是由于抑制与前额叶皮层和相关脑区功能障碍有关的不适当反应的能力受损所致。从我们的核心样本65药物治疗精神分裂症和44匹配的正常人的数据收集是完整的。然而，我们将继续测试药物和非药物状态下的受试者。为了阐明药物治疗的心理效应的性质，并探讨典型和非典型抗精神病药物之间的差异，我们已经开发了一些新的实验程序，精细地检查选择性注意和负启动的时间维度。我们还修改了精神分裂症受试者的工作记忆和负启动的新的实验措施。此外，我们继续准备分析数据，并对已经准备好的数据进行分析。今年，我们特别关注了眼动测量中涉及的复杂问题。从这些实验中得到的数据，再加上我们在同一受试者身上收集到的其他数据，都表明精神分裂症患者在50到150毫秒范围内存在特定记忆缺陷的可能性。如果是这样的话，这也表明精神分裂症患者可能不会将现实体验为连续的流动。- 精神分裂症，眼动，认知，工作记忆-人类受试者：仅访谈，问卷调查或调查

This project uses experimental psychological techniques to examine whether schizophrenic deficits in ocular-motor, cognitive and social tasks result from an impaired ability to suppress inappropriate responses linked to dysfunction of the prefrontal cortex and related brain areas. Data collection from our core sample of 65 medicated schizophrenics and 44 matched normals is complete. We are, however, continuing to test subjects available in both a medicated and a drug free state. In order to elucidate the nature of the psychological effects of pharmacological treatments and to explore differences between typical and atypical neuroleptics, we have developed some new experimental procedures that finely examine the temporal dimensions of selective attention and negative priming. We have also modified for use by schizophrenic subjects new experimental measure of working memory and negative priming. In addition, we continued the tasks of preparing our data for analysis and carrying out analyses of already prepared data. This year we paid particular attention to the complex issues involved in eye-movement measurement. The data from these experiments together with other data we have collected on the same subjects raise the possibility of a particular memory deficit in schizophrenic individuals in the 50 to 150 ms range. If this is the case, it would also suggests that schizophrenics may not experience reality as a continuous flow. - Schizophrenic, ocular-motor, cognitive, working memory - Human Subjects: Interview, Questionaires, or Surveys Only