ROLE OF NASAL STEROIDS ON PERENNIAL RHINITIS & INDUCED SLEEP DISTURBANCES

过敏性鼻炎的主要表现之一是充血。 鼻充血可使个体易患睡眠呼吸暂停， 微觉醒这种睡眠障碍会导致白天嗜睡 和疲劳。使用鼻用类固醇可以有效地减少 客观上和主观上都是如此。目前，没有研究 可用，显示鼻阻力，睡眠 与鼻用类固醇有关的觉醒和日间疲劳。的 这项研究的主要目的是证明鼻用类固醇可以 减少充血，从而减少睡眠障碍， 睡眠障碍的减少将导致白天睡眠时间的减少。 疲劳和嗜睡。20例常年性变应性鼻炎患者 将被选中参加。他们必须有主观的发现 鼻塞和睡眠障碍与相关的白天 疲劳本研究将是一项交叉、双盲安慰剂研究 为期八周的对照研究。每个参与者将开始 研究的活动期为4周，交叉至 研究的另一个分支持续四周。程序包括一个 病史、完整体格检查、鼻炎严重程度 问卷调查，点刺过敏试验，睡眠障碍量表 （Hoddes 1978）和每日睡眠日记，白天疲劳和鼻 症状

One of the main manifestations of allergic rhinitis is congestion. Nasal congestion can predispose the individual to sleep apnea and microarousals. This sleep disturbance can result in daytime somnolence and fatigue. The use of nasal steroids has been effective at reducing congestion, both objectively and subjectively. Presently, no study is available that shows objective decrease in nasal resistance, sleep arousals, and daytime fatigue in association with nasal steroids. The key objectives of this study are to demonstrate that nasal steroids can decrease congestion resulting in less sleep disturbances and that reduction of sleep disturbances will result in a reduction of daytime fatigue and somnolence. 20 candidates with perennial allergic rhinitis will be selected for participation. They must have subjective findings of nasal obstruction and of sleep disturbances with associated daytime fatigue. This study will be a cross-over, double-blinded placebo controlled study over eight weeks. Each participant will begin the active phase of the study for four weeks with a crossover to the alternative arm of the study for four weeks. Procedures include a medical history, complete physical exam, rhinitis severity questionnaire, prick allergy skin testing, scale for sleep disfunction (Hoddes 1978) and daily diary for sleep, daytime fatigue and nasal symptoms.