LUNG VOLUME REDUCTION SURGERY FOR EMPHYSEMA

最近的证据表明，肺减容手术（LVRS）可能是终末期肺气肿患者的一种有用的治疗选择。初步数据表明，LVRS可以改善肺弹性后坐力和呼吸肌功能，从而改善严重肺气肿患者的气流和运动耐受性。对某些人来说，这已经转化为生活质量的显著提高。然而，关于手术的许多问题仍然存在，包括肺功能的改善是否持久，以及手术的风险/益处究竟是什么。此外，关于适当的筛选试验和应该选择的理想患者进行这类手术的许多问题仍然存在。为了解决这些问题，美国国立卫生研究院和卫生保健财务管理局资助了一项多中心研究。俄亥俄州立大学医学中心被选为参与这项随机临床试验的18个中心之一。

Recent evidence has suggested that lung volume reduction surgery (LVRS) may be a useful therapeutic option for patients with end stage emphysema. Preliminary data has suggested the LVRS may improve lung elastic recoil as well as respiratory muscle function thereby improving air flow and exercise tolerance in patients with severe emphysema. In certain individuals this has translated into substantially improved quality of life. However, numerous questions remain regarding the surgery including whether or not the improvement in lung function is longlasting and what precisely are the risks/benefits of the procedure. Furthermore, numerous questions remain regarding the appropriate screening tests and the ideal patients that should be selected for this type of surgery. In order to address these questions, a multi-center study has been funded by the NIH and the Health Care Financing Administration. The Ohio State University Medical Center has been selected as one of 18 centers participating in this randomized clinical trial.