ID R1 ONCOGENE & ITS PRODUCT FROM RHADINOVIRUS OF RHESUS: KS MODEL

NERPRC的SPF计划是富有成效的，并一直保持着 1998年连续8年无病原菌，我们纳入了40岁的养殖年龄 雌性和8只繁殖年龄的雄性，进入我们的SPF定时交配群体 我们有75只两岁和三岁的第二代SPF动物 已经被确定为替代繁殖者，并预计 确定另外50只出生于1998年的动物作为 替补饲养员定期为这三只动物筛查所有动物 靶向逆转录病毒和B病毒是维持和衍生的关键 对SPF育种群建立的育种群进行筛选 每半年进行一次，除非意外情况下需要更频繁的测试 NERPRC SPF群体的临床疾病经历了高 1998年生育率和最低抗击怀孕率是 大约60%有20个稳定的后宫和12个小的后宫 所有雌性定时交配群组新后宫群组设立为 空间允许小后宫被招募到定时交配群中 最大限度地扩大空间SPF繁殖群体每年都会进行评估，而且年龄更大 或不高产的动物被分配到其他研究中

The NERPRC SPF program is productive and has remained pathogen-free for eight years In 1998, we incorporated 40 breeding age females and eight breeding age males, into our SPF timed-mating colony We have 75 two and three year old second generation, SPF animals that have been identified as replacement breeders and anticipate identifying an additional 50 animals born in 1998 to serve as replacement breeders Regular screening of all animals for the three target retroviruses and B Virus is the key to maintaining and deriving SPF breeding groups Established breeding groups are screened semiannually unless more frequent testing is warranted by unexpected clinical illness in the group The NERPRC SPF colony experiences high fertility and minimal fighting The pregnancy rate in 1998 was approximately 60% There are 20 stable harem groups and twelve small all female timed-mating groups New harem groups are established as space allows Small harems are recruited into timed-mating groups to maximize space The SPF breeding colony is evaluated annually and older or unproductive animals are assigned to other studies