Conference--Standards for Treatment of SLE Patients

描述(摘自申请者的摘要)：努力的目标 在这项赠款申请中提出的是举行一次协商一致的会议， 国际临床医生科学家和临床试验方法学家小组 制定系统性红斑狼疮的标准化反应标准 (SLE)以现有疾病活动性指标的“单位”为单位进行试验，并通过 选定的主要器官系统。系统性红斑狼疮的实验治疗领域是 在人类受试者身上的发现和评估的陡峭斜坡上 如果使用标准端点，则增强。标准响应标准将允许 试验之间有意义的比较，促进创新研究的使用 设计，大大提高了工作效率，缩短了工期 测试新的干预措施。这笔赠款将支持利益攸关方会议，以 根据来自国际组织的数据制定共识响应标准 会前练习，其中评估了1000多个患者的病历。 建立共识的技术，如Delphi和名义小组技术将 被利用。

DESCRIPTION (Taken from the applicant's abstract): The goal of the efforts proposed in this grant application is to conduct a consensus meeting of an international group of clinician-scientists and clinical trials methodologists to produce standardized response criteria for systemic lupus erythematosus (SLE) trials in the "units" of existing disease activity measures and by selected major organ systems. The field of experimental therapeutics in SLE is on a steep slope of discovery and their evaluation in human subjects will be enhanced if standard end points are used. Standard response criteria will allow meaningful comparisons between trials, promote the use of innovative study designs, and greatly improve the efficiency and shorten the time-line for testing new interventions. This grant will support a meeting of stakeholders to develop consensus response criteria based on data from an international pre-meeting exercise in which over 1000 patient histories were evaluated. Consensus building techniques, such as Delphi and nominal group techniques will be used.