High Mass Resolution for MALDI TOF Mass Spectrometry

描述(由申请人提供)：飞行时间MALDI的力量(矩阵 生物分子的辅助激光解吸电离和电喷雾 分析突然变得对大量 蛋白质化学家。灵敏度、质量分辨率和 这些光谱仪的质量精度可以在离子探测系统中找到。 通过攻击可以预期质谱计的实质性改进 限制当前使用的检测器的定时性能的问题。阶段 我公司已签订了OEM(原始设备制造)合同进行销售 我们用于TOF电喷雾的多通道TDC/探测器数据系统。第二阶段 创新和改进将通过与 德克萨斯A&M大学的David Russell博士和Kent Gillig博士，紧随其后的是Quick 通过我们现有的OEM合同在市场上实施。 建议的商业应用： 第一阶段创新的商业潜力已经通过OEM销售在电喷雾领域确立。第二阶段还应为MALDI中的检测和数据分析提供解决方案。代工和直销已经开始，并将扩大到包括第二阶段的改进和创新。

DESCRIPTION (provided by applicant)): The power of time of flight MALDI (matrix assisted laser desorption ionization) and electrospray for biomolecular analysis has suddenly become of indispensable utility to a huge number of protein chemists. The foremost limitation to sensitivity, mass resolution, and mass accuracy of these spectrometers can be found in the ion detection systems. Substantial improvements of the mass spectrometers can be expected by attacking problems which limit the timing performance of presently used detectors. Phase I has resulted in OEM (original equipment manufacture) contracts for sale of our multichannel TDC/detector data systems for TOF electrospray. Phase II innovations and improvements will be tested through a close collaboration with Dr. David Russell and Kent Gillig at Texas A&M University, followed by quick implementation in the marketplace through our existing OEM contract. PROPOSED COMMERCIAL APPLICATION: Commercial potential for the phase I innovations has already been established in the field of electrospray through OEM sales. Phase II should provide solution to detection and data analyis in MALDI as well. OEM and direct sales are already underway and would be expanded to include phase II improvements and innovations.