Nanoparticulate Coatings Enhance Ion Detection
Nanoparticulate Coatings Enhance Ion Detection
批准号:
10259237
负责人:
John Albert Schultz
金额:
$79.95万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-09-25 至 2023-08-31
关键词:
AlloysAreaAtmosphereBiological SciencesChargeComputer softwareDataDepositionDetectionDoseElectronsEquipmentFilmFluorescence MicroscopyGasesGoalsHeightHeliumIndividualIonsKineticsLegal patentMasksMeasurementMeasuresMethodsMicroscopeMicroscopyModelingModificationMorphologyOutcomePerformancePhasePhotonsPhysicsPhysiologic pulsePositron-Emission TomographySalesSourceSurfaceTechniquesTechnologyTestingThickThinnessTransmission Electron MicroscopyUnited States National Institutes of HealthWorkatomic layer depositionbasedata acquisitiondetectorimprovedion mobilitymass spectrometermicroporenanoparticulatenanoscaleparticlesuccesstime of flight mass spectrometrytool
中文摘要
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英文摘要
Project Summary
A new thin film deposition technique for increasing the gain and sensitivity of existing
microchannel ion detectors was proven in a previously completed NIH phase I. An increased
Secondary Electron (SE) yield from these films was found to improve with ion doses of helium
up to > 100 Coulombs/cm2 while the electron yield from the uncoated detector first surface
decreased after 1 Coulombs/cm2. A NIH Phase II will use these films to vary elemental
composition and morphology of the first surface to increase the first hit SE yield and to prolong
the deposited layer lifetime. Detector testing will proceed with in-house ion and electron
sources.
Methods for putting these thin film coatings onto the sidewalls of the MCP (in addition to
covering the front detector surface) should increase the detector gain and substantially prolong
the detector lifetime of commercially available MCPs.
We will emphasize use of the Zeiss Orion helium ion microscope at Rutgers to perform
accelerated lifetime testing of the MCP pulse height, gain and first surface secondary electron
yield from individual pores. Elemental composition change in the first hit area of the
microchannel pore will also be determined by Nanoscale Rutherford backscattering within the
Orion and will be correlated with the lifetime and yield measurement. The combination of the
Zeiss Orion configured with the Ionwerks NanoRBS spectrometer should prove to be a crucial
tool in detector physics. In addition the overall performance of the NanoRBS will improve when
this spectrometer is retrofitted with newly enhanced MCPs from this phase II effort.
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Nanoparticulate Coatings Enhance Ion Detection
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批准号:10883978
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项目类别:
-
资助金额:$4.0万
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财政年份:2014
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负责人:John Albert Schultz
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依托单位:
Biomarker Quantitation by NP-MS Tissue Imaging.
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批准号:8592448
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项目类别:
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资助金额:$95.72万
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财政年份:2013
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负责人:John Albert Schultz
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依托单位:
Biomarker Quantitation by NP-MS Tissue Imaging.
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批准号:8661740
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项目类别:
-
资助金额:$99.88万
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财政年份:2013
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负责人:John Albert Schultz
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依托单位:
Microfocused Nanoparticulate ions to enable intracellular molecular imaging.
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批准号:8473837
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项目类别:
-
资助金额:$76.06万
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财政年份:2011
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负责人:John Albert Schultz
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依托单位:
Microfocused Nanoparticulate ions to enable intracellular molecular imaging.
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批准号:8307366
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项目类别:
-
资助金额:$78.03万
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财政年份:2011
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负责人:John Albert Schultz
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依托单位:
Microfocused Nanoparticulate ions to enable intracellular molecular imaging.
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批准号:8059377
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项目类别:
-
资助金额:$79.99万
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财政年份:2011
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负责人:John Albert Schultz
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依托单位:
Infrared Laser Desorption Ion Mobility Mass Spectrometer
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批准号:7463890
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项目类别:
-
资助金额:$19.41万
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财政年份:2007
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负责人:John Albert Schultz
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依托单位:
Infrared Laser Desorption Ion Mobility Mass Spectrometer
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批准号:7273987
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项目类别:
-
资助金额:$19.94万
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财政年份:2007
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负责人:John Albert Schultz
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依托单位:
Infrared Laser Desorption Ion Mobility Mass Spectrometer
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批准号:7664534
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项目类别:
-
资助金额:$19.27万
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财政年份:2007
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负责人:John Albert Schultz
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依托单位:
Photofragmentation MS of Ion Mobility Separated Peptides
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批准号:6643145
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项目类别:
-
资助金额:$9.95万
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财政年份:2003
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负责人:John Albert Schultz
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依托单位:
High Mass Resolution for MALDI TOF Mass Spectrometry
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批准号:6529618
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项目类别:
-
资助金额:$37.5万
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财政年份:1998
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负责人:John Albert Schultz
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依托单位:
High Mass Resolution for MALDI TOF Mass Spectrometry
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批准号:6404266
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项目类别:
-
资助金额:$45.17万
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财政年份:1998
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负责人:John Albert Schultz
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依托单位:
HIGH MASS RESOLUTION FOR MALDI TOF MASS SPECTROMETRY
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批准号:2649433
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项目类别:
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资助金额:$9.99万
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财政年份:1998
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负责人:John Albert Schultz
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依托单位:
ULTRA SENSITIVE MULTIHIT ION DETECTOR--TOF BIOMASSPEC
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批准号:2420769
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项目类别:
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资助金额:$9.89万
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财政年份:1997
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负责人:John Albert Schultz
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依托单位:
国内基金
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层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
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批准号:2021JJ40433
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项目类别:省市级项目
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资助金额:--
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批准年份:2021
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负责人:孙磊
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依托单位:
寄主诱导梢腐病菌AreA和CYP51基因沉默增强甘蔗抗病性机制解析
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批准号:32001603
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项目类别:青年科学基金项目
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资助金额:24.0万元
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批准年份:2020
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负责人:段真珍
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依托单位:
AREA国际经济模型的移植.改进和应用
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批准号:18870435
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项目类别:面上项目
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资助金额:2.0万元
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批准年份:1988
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负责人:史树中
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依托单位: