DIABETES PREVENTION TRIAL-TYPE 1 DIABETES (DPT-1)

本多中心随机试验旨在评价低剂量胰岛素治疗联合周期性持续胰岛素输注（“β细胞静息”）延迟和/或预防胰岛素依赖型糖尿病患者一级亲属发生胰岛素依赖型糖尿病的能力。 非糖尿病、胰岛细胞抗体阳性且第一时相胰岛素分泌也有改变的个体有资格进行随机化。在过去的一年中，大约100个曾经参加过糖尿病遗传学研究的胰岛素依赖型糖尿病家庭被联系并被告知DPT-1试验。对一些感兴趣的家庭成员进行了抗体筛查，但未发现伊卡+个体。明年将继续招聘。

This multicenter randomized trial is designed to evaluate the ability of low dose insulin therapy, in association with periodic continuous insulin infusions ('beta cell rest') to delay and/or prevent the development of insulin dependent diabetes in first degree relatives of individuals with IDDM. Nondiabetic, islet cell antibody positive individuals who also have alterations in first phase insulin secretion are qualified for randomization. During the past year, approximately 100 IDDM families who had participated in previous studies of the genetics of diabetes were contacted and informed about the DPT-1 trial. Antibody screening of some interested family members was performed but no ICA+ individuals were identified. Recruitment will continue in the coming year.