EFFECT OF DIET ON OCCURENCE OF CHRONIC DISEASE

目的：饮食可能会影响几种慢性人类疾病的风险，但还需要进一步的研究。这个项目有两个主要推动力。一个是饮食与癌症关系的研究；另一个是饮食与肌萎缩侧索硬化症(ALS)风险的研究。补充：抗氧化剂防御系统的缺陷(如超氧化物歧化酶1[SOD1])是ALS的原因，因此有理由怀疑抗氧化剂的摄入也可能影响这种疾病的发生或进展。关于饮食和肌萎缩侧索硬化症，其中一个重点是对卡迈尔博士关于肌萎缩侧索硬化症的病例对照研究的饮食数据的分析(正在出版中)。同样的关系的第二项研究是国家癌症研究所正在进行的一项大型队列研究的补充。该队列由美国退休人员协会(AARP)的成员组成，他们已经完成了饮食调查问卷(约60万人)。我们预计到2002年将有大约150例肌萎缩侧索硬化症在这个队列中发展。

Aims:Diet may affect the risk of several chronic human diseases but additional research is needed. This project has two main thrusts. One is the study of diet-cancer relations; the other is the study of diet in relation to risk of amyotrophic lateral sclerosis (ALS).Accomplishments: Defects in antioxidant defenses (e.g., superoxide dismutase 1 [SOD1]) are a cause of ALS, thus it is reasonable to suspect that antioxidant intake may also affect the incidence or progression of this disease. Regarding diet and ALS, one thrust has been an analysis of dietary data from Dr. Kamel's case-control study of ALS (in press). A second study of the same the relation is an add-on to a large cohort study underway at the National Cancer Institute. The cohort consists of members of the American Association of Retired Persons (AARP) who have completed a dietary questionnaire (approximately 600,000 people). We expect about 150 cases of amyotrophic lateral sclerosis to develop in this cohort by 2002.