Assessment of Lymphocytes in Patients with Autoimmune Lymphoproliferative Syndro
Assessment of Lymphocytes in Patients with Autoimmune Lymphoproliferative Syndro
批准号:
6431853
负责人:
thomas a fleisher
金额:
$0.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
一个广泛的流式细胞术评估继续与自身免疫性淋巴组织增生综合征(ALPS)患者及其大家庭成员,扩展的双阴性T细胞和B细胞群体的特征的基础上。双阴性T细胞已被证明是α β TcR、CD 57+、HLA-DR+和CD 45 RA+。这项研究已经扩展到更完整地表征双阴性T细胞,包括所有ALPS患者中的γ-δ TcR T细胞。此外,我们已经开始扩大表征的B细胞,针对记忆B细胞,在这些患者。
英文摘要
An extensive flow cytometric evaluation continues of patients with autoimmune lymphoproliferative syndrome (ALPS) and their extended family members, on the basis of characterization of the expanded double-negative T-cell and B-cell populations. Double-negative T-cells have been demonstrated to be alpha beta TcR, CD57+, HLA-DR+, and CD45RA+. This study has been extended to characterize the double-negative T-cells more completely including gamma-delta TcR T-cells in all ALPS patients. In addition, we have initiated expanded characterization of the B cells, directed at memory B cells, in these patients.
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