Effect of liver pathophysiology on hepatic pharmacokinetics

肝脏是体内天然和外源溶质代谢和胆汁排泄的主要器官。各种肝脏疾病，如肝硬化、酒精性肝病、饮食和药物诱导的脂肪肝可影响药物的摄取和代谢及其适用性-给药需求。一些肝脏疾病如脂肪肝非常常见，但药物在这些患者中的代谢速度尚不清楚。这项工作很重要，因为它可以帮助我们更好地设计新药，更好地选择给药的药物，以及剂量。此外，许多肝脏疾病需要活检以明确诊断肝脏的可能功能。肝功能的估计在估计是否有足够的储备切除癌症或决定是否需要肝移植时特别重要。肝脏也是一个非常复杂的器官，可以通过一系列不同的系统捕获或分解溶质。同样重要的是这些疾病如何影响肝脏中的药物分布，因为改变的肝脏药物分布可能影响对药物及其代谢物的全身反应。这项工作试图回答这些问题。

The liver is the main organ in the body for the metabolism and biliary excretion of natural and foreign solutes. Various liver diseases such as cirrhosis, alcoholic liver disease, diet and drug induced fatty livers can affect the uptake and metabolism of drugs and their suitability- dosing needs. Some liver diseases such as fatty livers are very common but how rapidly drugs are metabolised in these patients is not well described. The work is important as it may help us better design new drugs and better choose which drugs to give and, if so, in what doses. In addition, many liver diseases require a biopsy for a definite diagnosis of the likely function of the liver. Estimation of liver function is particularly important in estimating whether there will be sufficient reserve on resection of a cancer or deciding if a liver transplant is needed. The liver is also a very complex organ which can trap or breakdown solutes by a range of different systems. Also of importance is how those diseases affect drug disposition in the liver given that an altered hepatic drug disposition may affect systemic response to the drugs and their metabolites. This work seeks to answer these questions.