Novel Vehicle for Topical Delivery of Corticosteroids

描述（由申请人提供）：局部皮质类固醇是许多皮肤病的有效治疗方式。大多数局部皮质类固醇以乳膏或软膏媒介物施用，其需要多次施用，容易被无意中移除，并且可能是化妆品不可接受的。虽然已证明使用水胶体封闭敷料可提高疗效，但这些敷料通常与局部副作用和固有的美容缺陷相关。 本项目的目的是证明使用新型涂层技术作为皮质类固醇局部给药载体的可行性，同时作为半封闭敷料。将配制并检测浸渍有皮质类固醇的涂层，以证明其在人体血管收缩试验中的有效性。 建议的商业应用：局部皮质类固醇是皮肤科最广泛使用的制剂。一种能够提高疗效并减少治疗同时具有成本效益的新型载体将具有巨大的商业潜力。

DESCRIPTION (provided by applicant): Topical corticosteroids are useful treatment modalities for numerous dermatologic conditions. Most topical corticosteroids are applied in a cream or ointment vehicle, which require multiple applications, are subject to inadvertent removal, and can be cosmetically unacceptable. While efficacy has been shown to be increased with the use of hydrocolloid occlusive dressings, these dressings are often associated with local side effects and inherent cosmetic deficiencies. The goal of this project is to demonstrate the feasibility of using a novel coating technology as a topical delivery vehicle for corticosteroids that simultaneously serve as a semi-occlusive dressing. Coatings impregnated with corticosteroid will be formulated and tested to demonstrate efficacy in the vasoconstrictor assay in humans. PROPOSED COMMERCIAL APPLICATION: Topical corticosteroids are the most widely used preparations in dermatology. A novel vehicle that could improve efficacy and reduce treatments while being cost-effective would have significant commercial potential.