Training--Signal Transduction and Cellular Endocrinology

描述（由申请人提供）：本竞争性续期申请为伊利诺伊大学芝加哥分校信号转导和细胞内分泌学现有培训项目的继续提供资金。该项目提供信号转导、基因转录/翻译和细胞内分泌学等相关领域的跨学科培训，重点研究信号转导和调节细胞、组织和有机体对外部环境的反应的细胞和分子机制。培训计划的持续目标是培养独立的基础科学和临床研究人员，并在信号转导，细胞内分泌学和基因转录/翻译的广泛方面培养博士候选人。该培训计划的一个潜在主题是协调和促进博士后和博士后研究人员之间的相互作用，他们使用不同的实验系统和方法来理解包括分子、细胞和综合生物学在内的各种组织水平的信号转导机制。该培训项目跨越学科和院系，利用来自医学院六个基础科学系（解剖学和细胞生物学、生物化学和分子生物学、分子遗传学、微生物学和免疫学、药理学、生理学和生物物理学）和三个临床科室（血液肿瘤学、内分泌学和代谢学、风湿病学）的33名教员的专业知识。并利用分子、生化、生理、遗传和结构生物学的广泛方法，为信号转导和相关领域的广泛问题提供机会。信号传导、细胞周期调控、基因转录、癌症生物学、发育生物学、内分泌和神经体液信号传导等领域代表了UIC研究人员的主要优势，这些研究人员来自所有这些群体。博士前培训包括理论、技术和研究视角，通过教学课程、研究报告、研讨会、非正式互动、研究轮岗和年度静修。信号转导、内分泌学的课程，以及分子和细胞生物学、生物化学、遗传学、结构生物学、生理学和药理学的核心课程，科学传播和负责任的研究行为，为密集的研究环境提供了基础。教师培训师的研究兴趣包括神经体液信号，膜受体和转导机制，第二信使，细胞周期控制，转录/翻译调节和结构生物学。博士后接受两年或三年的培训，根据他们的研究兴趣、背景和具体的课程需求进行培训。所有学员都是信号转导和其他研讨会的参与者，以及该计划支持的年度芝加哥大都会区信号转导研讨会的参与者。培训计划强调当代信号转导研究的跨学科性质，在培养独立和创造性思维的环境中。我们期望该项目最终能够培养出一批杰出的独立研究者，他们将在信号转导的广泛领域做出重大贡献，并最终为丰富科学进步和社区服务。

DESCRIPTION (provided by applicant):This competitive renewal application requests funding for the continuation of the existing Training Program in Signal Transduction and Cellular Endocrinology at the University of Illinois at Chicago. This predoctoral and postdoctoral training program provides interdisciplinary training in the related fields of signal transduction, gene transcription/translation, and cellular endocrinology, with emphasis on both cellular and molecular mechanisms that transduce signals and regulate cell, tissue and organismal responses to their external environment. The continuing goal of the training program is to develop independent basic science and clinical investigators, and to train doctoral candidates in broad aspects of signal transduction, cellular endocrinology, and gene transcription/translation. An underlying theme in this training program has been the coordination and promotion of interactions between pre-and post-doctoral researchers who are using different experimental systems and approaches toward understanding signal transduction mechanisms at various levels of organization including molecular, cellular and integrative biology. The training program crosses both disciplinary and departmental lines, drawing upon the expertise of thirty-three faculty from six basic science departments (anatomy and cell biology, biochemistry and molecular biology, molecular genetics, microbiology and immunology, pharmacology, physiology and biophysics) and three clinical sections (hematology-oncology, endocrinology and metabolism, rheumatology) in the Department of Medicine, and offering opportunities in a wide range of problems in signal transduction and allied areas using a broad spectrum of molecular, biochemical, physiologic, genetic, and structural biology approaches. The areas of signaling, cell cycle regulation, gene transcription, cancer biology, developmental biology, and endocrine and neurohumoral signaling represent major strengths of researchers at UIC and preceptors have been drawn from all these groups. Predoctoral training includes theory, techniques and research perspectives through didactic courses, research presentations, seminars, informal interactions, research rotations, and a yearly retreat. Courses in signal transduction, endocrinology, and a core curriculum in molecular and cellular biology, biochemistry, genetics, structural biology, physiology, and pharmacology, scientific communication, and responsible conduct of research provide the foundation for an intensive research environment. Faculty trainers' research interests range from neurohumoral signaling, membrane receptors and transduction mechanisms, to second messengers, cell cycle control, transcriptional/translational regulation, and structural biology. Postdoctoral fellows are trained in two or three year programs tailored to their research interests, background and specific course needs. All trainees are participants in Signal Transduction and other seminars, and an annual Chicago metropolitan area Signal Transduction Symposium which the program supports. The training program emphasizes the interdisciplinary nature of contemporary research in signal transduction in an environment that fosters independent and creative thinking. We anticipate that the program will ultimately contribute to the generation of outstanding independent investigators who will make significant contributions in the broad area of signal transduction, and who will ultimately serve to enrich scientific progress and community.