New Non-invasive Imaging Methods For Biomedical Applicat

在过去的一年里，我们集中精力，并取得了进展，在该领域的定量收缩功能评估的人心脏在体内。基于本课题组提出并成功应用于人体心脏显微成像的受激回波相衬法DENSE，我们优化了用于患者单次屏气体内应用的技术。使用最先进的1.5特斯拉全身临床扫描仪，该技术现在能够在15次心跳的屏气中量化整个左心室壁在三维空间中的运动。对于其他需要屏气以上的心脏MRI检查，我们开发了一种运动导航器技术，可以跟踪心脏的实际位置，与基于隔膜的方法相比，该技术提高了个体患者的可靠性。使用这种方法，可以在正常呼吸条件下可靠地进行许多检查。我们还展示了一种新的矢量化运动成像方法，可能在小动物MRI中有有趣的应用。

In the last year we focused our effot and made progress in the area of quantitative contractile function assessment of the human heart in vivo. Based on the stimulated-echo phase contrast method DENSE, which was proposed for micro-imaging and applied successfully in the human heart by our group,we optimized the technique for single breath-hold in vivo application in patients. Using a state-of-the-art 1.5 tesla whole-body clinical scanner, the technology is now able to quantify the motion of the entire left ventricular wall in three-dimensional space in a breath-hold of 15 heartbeats. For other cardiac MRI exams that need more than a breath-hold, we developed a motion-navigator technique that tracks the actual position of the heart from beat to beat, with improved reliability for individual patients than diaphragm based methods. With this method, many exams can be reliably performed under normal breathing condition. We also demonstrated a novel vectorized motion imaging method that may have interesting applications in small animal MRI.