CORE--REPRODUCTIVE TOXICOLOGY

描述（由申请人提供）：生殖和发育 毒理学研究中心负责五个子专业的活动 地区这些活动包括开发新的实验室 以人口为基础的人类健康研究的分析方法。研究 本核心的活动采取多学科方法来解决问题 与人类生殖健康有直接关系。他们涉及一个或 更多的设施核心成员，通常至少有一个设施核心的支持。 核心成员使用的实验设计包括临床研究， 动物模型的体内研究和体外机制研究。 从历史上看，这一核心一直活跃在流行病学和分子生物学领域。 生殖毒理学方面。对于前一个方面，目标是 开发和应用可靠的生物标志物/分析方法， 问题研究对于后一个方面，目标是了解机制， 哪些外源性物质会对雄性和雌性最脆弱的过程产生不利影响， 女性生殖。

Description (provided by applicant): The Reproductive and Developmental Toxicology Research Core is responsible for activities in five sub-specialty areas. These activities range from the development of new laboratory analytical methods to population-based studies of human health. The research activities in this Core take a multi-disciplinary approach to solving problems that have direct relevance to human reproductive health. They involve one or more Facility Core members and usually at least one Facility Core for support. Experimental designs used by Core members include clinical investigations, in vivo studies with animal models, and in vitro mechanistic studies. Historically, this Core has been active in both epidemiological and molecular aspects of reproductive toxicology. For the former aspect, the goal is to develop and apply reliable biomarkers/analytical methods for population-based studies. For the latter aspect, the goal is to understand the mechanism, by which xenobiotics adversely affect the most vulnerable processes of both male and female reproduction.