Effect Of Diet On Occurence Of Chronic Disease

目的：饮食可能影响几种慢性人类疾病的风险，但需要进一步的研究。这个项目有两个重点。一个是饮食与癌症关系的研究；另一个是研究饮食与肌萎缩性侧索硬化症（ALS）风险的关系。研究成果：抗氧化防御的缺陷（如超氧化物歧化酶1 [SOD1]）是ALS的病因之一，因此我们有理由怀疑抗氧化剂的摄入也可能影响该疾病的发生或进展。关于饮食和肌萎缩侧索硬化症（ALS），一个重点是对卡梅尔博士的ALS病例对照研究（今年发表）的饮食数据进行分析。美国国家癌症研究所（National Cancer Institute）正在进行的一项大型队列研究中，另一项研究是对这一关系的补充。该队列由美国退休人员协会（AARP）的成员组成，他们完成了一份饮食调查问卷（大约60万人）。我们预计到2002年将有150例肌萎缩性侧索硬化症。

Aims: Diet may affect the risk of several chronic human diseases but additional research is needed. This project has two main thrusts. One is the study of diet-cancer relations; the other is the study of diet in relation to risk of amyotrophic lateral sclerosis (ALS). Accomplishments: Defects in antioxidant defenses (e.g., superoxide dismutase 1 [SOD1]) are a cause of ALS, thus it is reasonable to suspect that antioxidant intake may also affect the incidence or progression of this disease. Regarding diet and ALS, one thrust has been an analysis of dietary data from Dr. Kamel's case-control study of ALS (published this year). A second study of the same the relation is an add-on to a large cohort study underway at the National Cancer Institute. The cohort consists of members of the American Association of Retired Persons (AARP) who have completed a dietary questionnaire (approximately 600,000 people). We expect about 150 cases of amyotrophic lateral sclerosis to develop in this cohort by 2002.