Phenolphthalein Containing Laxative Use And Neoplasia

目的：酚酞是许多泻药中的一种成分，在国家毒理学计划(NTP)最近完成的为期两年的啮齿动物喂养研究中，显示出明显的致癌活性。大约3%的美国老年人口每天使用含有酚酞的泻药。我们将在人类中调查含有酚酞的泻药使用与卵巢癌和腺瘤性结直肠息肉风险的关系。成就：我们与主要研究人员就卵巢癌危险因素的两项病例对照研究建立了合作协议。在我们的怂恿下，这些研究人员在他们的调查问卷中插入了一份2页的附加内容，以确定特定的含酚酞泻药的使用。发表了第一个此类研究的报告，其余研究(300个病例和300个对照)的数据将在2001年准备好进行分析。这份已发表的报告显示，含有酚酞的泻药的使用与卵巢癌的风险没有关联。我们可以从两项腺瘤性大肠息肉危险因素的病例对照研究中获得有关泻药使用的数据。在这些数据中，我们检查了泻药的使用与息肉风险的关系。在考虑了饮食和其他结直肠腺瘤的危险因素后，专门探讨了息肉与所有泻药和含有酚酞的泻药的使用之间的关系。这两项研究的结果彼此不一致，但总的来说，几乎不支持使用含酚酞的泻药与息肉风险之间的联系。该报告发表于1997年。

Aims: Phenolphthalein, a constituent in many laxatives, showed clear evidence of carcinogenic activity in 2-year feeding studies in rodents recently completed by the National Toxicology Program (NTP). About 3% of the older U.S. population uses phenolphthalein-containing laxatives on a daily basis. We will investigate the relation of phenolphthalein-containing laxative use with risk of ovarian cancer and adenomatous colorectal polyps in humans. Accomplishments: We established collaborative agreements with the principal investigators for two case-control studies of risk factors for ovarian cancer. At our instigation, these investigators inserted into their questionnaire a 2-page addition that ascertains use of specific phenolphthalein-containing laxatives. A report from the first such study was published and data from the remaining study (300 cases and 300 controls) will be ready for analysis in 2001. The published report shows no association of phenolphthalein-containing laxative use and risk of ovarian cancer. Data on laxative use were available to us from two case-control studies of risk factors for adenomatous colorectal polyps. We examined laxative use in relation to risk of polyps in these data. The association of polyps with use of all laxatives and phenolphthalein-containing laxatives was specifically explored after taking into account dietary and other risk factors for colorectal adenomas. Results from the two studies were inconsistent with each other but overall offered little support for an association between phenolphthalein-containing laxative use and risk of polyps. The report was published in 1997.