Core--Neuropathology

描述：(改编自应用程序) 神经病理核心(核心C)安排和进行尸检，执行 人类受试者的神经病理学评估(核心B，项目4)，以及 协助评估AD转基因(TG)动物模型(项目 1-3)。为了支持需要人类大脑的研究，Core C运行 脑资源中心(BRC)，固定/冷冻尸检组织的储存库。 核心C的教员在培养基础科学家和 研究衰老和神经退行性疾病病理学的内科医生咨询 关于痴呆症病例的外部病理学家，以及基因分型是否相关 到公元后。Core C预期尸检计划是独一无二的，因为 巴尔的摩老龄化纵向研究的对照受试者比例 (BLSA)(核心B)在未来五年，预计总共将有 113具身体解剖，其中71具将是来自 国土安全部。这些人中的许多人将进行神经成像研究作为一部分 一项与之平行的NIA研究。这些受试者的组织，以及其他组织 AD案例，将访问BRC，并将继续制作 可供研究，不仅在ADRC内部，而且对科学界 整个社区。Core C将支持对TG小鼠的形态研究 总结AD的几个病理特征(项目1-3)。这些 同源基因Mo/HuAPPswe TG小鼠行为特征谱系概述 阿尔茨海默病的几个病理特征(方案1-3)。其中许多 分析将需要定量形态测量，因此支持将 需要组织学实验室和体视学单位的协助。 通过这些多项活动，Core C负责促进和协调 项目1-4中临床和实验材料的评价， 从而大大增强了我们的诊断和研究能力 ADRC。

DESCRIPTION: (Adapted from the application) The Neuropathology Core (Core C) arranges and conducts autopsies, performs neuropathological evaluations of human subjects (Core B, Project 4), and assists in the assessment of transgenic (Tg) animal models of AD (Projects 1-3). To support research that requires brains from humans, Core C operates the Brain Resource Center (BRC), a repository of fixed/frozen autopsy tissues. The faculty of Core C plays a critical role in training basic scientists and physicians in the pathology of aging and neurodegenerative diseases, consults with outside pathologists on cases of dementia, and does genotyping relevant to AD. The Core C prospective autopsy program is unique because of the large proportion of control subjects from the Baltimore Longitudinal Study of Aging (BLSA) (Core B). During the next five years, it is projected that a total of 113 autopsies, 71 of which will be longitudinally characterized subjects from the BLSA. Many of these individuals will have had neuroimaging studies as part of a parallel NIA study. Tissues from these subjects, as well as from other cases of AD, will be accessed to the BRC and will continue to be made available for research, not only within the ADRC, but to the scientific community at large. Core C will support morphological studies of Tg mice that recapitulate several of the pathological features of AD (Projects 1- 3). These lines of behaviorally characterized congenic Mo/HuAPPswe Tg mice recapitulate several of the pathological features of AD (Projects 1-3). Many of these analyses will require quantitative morphometry and, therefore, support will require the assistance of the histology laboratory and stereology unit. Through these multiple activities, Core C acts to facilitate and coordinate the evaluations of both clinical and experimental material in Projects 1-4, thereby greatly enhancing the diagnostic and research capabilities of our ADRC.