CCCWFU Research Base Grant

描述(由申请人提供)： 维克森林大学(CCCWFU)综合癌症中心(CCCWFU)社区临床肿瘤学项目(CCOP)研究基地于1999年9月(追溯至1999年6月)资助三年。本申请书描述了研究基地的管理结构，包括安全和监测程序以及研究基地的临床研究活动，该研究基地作为控制/治疗CCOP研究基地进行了为期五年的竞争性续期。研究基地的参与者包括三个CCOP(南卡罗来纳州温斯顿-塞勒姆东南癌症控制联盟、南卡罗来纳州斯帕坦堡北卡罗来纳州CCOP、南卡罗来纳州格林维尔格林维尔CCOP)和四个非CCOP预防成员(北卡罗来纳州格林维尔东卡罗来纳大学、北卡罗来纳州高点地区卫生系统、佐治亚州罗马社区癌症中心和北卡罗来纳州卡里的WakeMed系统)。这三个CCOP和四个预防成员覆盖的地理区域包括七个州(北卡罗来纳州、南卡罗来纳州、 弗吉尼亚州、西弗吉尼亚州、肯塔基州、田纳西州、佐治亚州)拥有约1200万人口，其中四分之一是少数民族(60%是沿海北卡罗来纳州社区的少数民族)，由28个癌症中心提供服务。预计在12/01年前，还将有3-6名CCOP和少数族裔CCOP加入CCCWFU CCOP研究基地。申请中描述了研究基地正在进行的和正在进行的临床试验。在癌症控制方面，有4个正在进行中，13个正在发展中 研究侧重于以下领域：免费和替代医学、症状管理和生活质量，特别是在与癌症相关的疲劳、厌食症/体重减轻、抑郁、潮热、认知和化学预防方面。在癌症治疗方面，有6项正在进行的研究和7项正在进行中的研究，主要集中在补充、替代和常规治疗上，主要用于肺癌、胰腺癌和脑癌。的光谱 CCCWFU CCOP研究基地提供的临床研究是对合作小组研究基地提供的癌症控制/治疗方案的补充，而不是竞争。在首席研究员Edward G.Shaw，M.D.的指导下，CCCWFU的临床研究管理行政结构和主要领导 来自CCCWFU、CCOP和预防成员的CCCWFU CCOP研究基地 正在实现其主要目标，即向美国东南部的CCOP和患者(包括少数族裔)提供最先进的以干预为导向的癌症预防/控制临床研究。

DESCRIPTION (provided by applicant): The Comprehensive Cancer Center of Wake Forest University (CCCWFU) Community Clinical Oncology Program (CCOP) Research Base was funded in 9/99 (retroactive to 6/99) for three years. This application describes the administrative structure, including safety and monitoring procedures and clinical research activities of the Research Base for its five-year competitive renewal as a control/treatment CCOP Research Base. Participants in the Research Base include three CCOPs (Southeast Cancer Control Consortium, Winston-Salem, NC; Upstate Carolina CCOP, Spartanburg, SC; Greenville CCOP, Greenville SC) and four non-CCOP Prevention Members (East Carolina University, Greenville, NC; High Point Regional Health System, High Point, NC; InterCommunity Cancer Center, Rome, GA; WakeMed System, Cary, NC. The geographic region covered by these three CCOPs and four Prevention Members includes seven states (NC, SC, VA, WV, KY, TN, GA) with a population of approximately 12 million people, one-quarter of whom are minorities (60% minorities in coastal NC communities), served by 28 cancer centers. It is anticipated that an additional 3-6 CCOPs and Minority-Based CCOPs will join the CCCWFU CCOP Research Base by 12/01. Active and developing clinical trials of the Research Base are described in the application. In cancer control, there are 4 active and 13 developing studies, focusing on the following areas: complimentary and alternative medicine, symptom management, and quality of life, particularly in the setting of cancer related fatigue, anorexia/weight loss, depression, hot flashes, cognition and chemoprevention. In cancer treatment, there are 6 active and 7 developing studies, focusing on complementary, alternative, and conventional therapies primarily in lung, pancreas, and brain cancer. The spectrum of clinical research studies offered by the CCCWFU CCOP Research Base is complementary to, rather than competitive with, the cancer control/treatment protocols offered by the Cooperative Group Research Bases. Under the direction of Principal Investigator Edward G. Shaw, M.D., the Clinical Research Management administrative structure of the CCCWFU, and key leadership from the CCCWFU, CCOPs, and Prevention Members, the CCCWFU CCOP Research Base is fulfilling its primary goal of providing state-of-the-art intervention oriented clinical research studies in cancer prevention/control to CCOPs and patients (including minorities) in the Southeast United States.