INSTRUMENTATION GRANT FOR RESEARCH ECHOCARDIOGRAPHY

爱荷华大学的研究人员请求支持购买Acuson Sequoia C256心脏超声成像仪。该提案促进了具有不同兴趣和背景的研究人员的目标-从综合生理学到基础分子科学。该仪器的两个主要用户，费尔德和科伯，是研究人员和临床心脏病专家。他们已经将超声心动图用于临床诊断以及研究环境中。剩下的五个主要用户是非内科基础科学家。该提案解决了这些研究人员评估小鼠、大鼠和更大动物的整个器官功能，主要是心脏功能的需要。所有研究人员都致力于从机制上理解心血管疾病。该仪器将提供为这些目标量身定做的数据。初步研究已经使用位于偏远地点的类似仪器进行，爱荷华市退伍军人医疗中心。这些研究表明，该仪器能够非侵入性地提供准确、可靠的图像数据。不幸的是，该仪器的偏远位置，以及它作为临床成像仪的全职使用，对可以进行的实验的数量和复杂性施加了严重的限制。这些研究表明，该仪器能够非侵入性地提供准确、可靠的图像数据。不幸的是，这项实验的偏远地点，以及它作为临床成像仪的全职使用，对可以进行的实验的数量和复杂性施加了严重的限制。为了追求研究人员的目标，我们要求一种完全用于实验动物研究的仪器。

Investigators from the University of Iowa request support to purchase an Acuson Sequoia c256 cardiac ultrasound imager. The proposal fosters the Aims of investigators with diverse interests and backgrounds-ranging from integrative physiology to basic molecular science. Two of the primary Users of the instrument, Felder and Kerber, are researchers and clinical cardiologists. They have employed echocardiography for clinical diagnosis as well as in the research setting. The remaining five primary Users are non-physician basic scientists. The proposal addresses the need for these investigators to assess whole organ function, primarily cardiac, in mice, rats, and larger animals. All investigators address Aims directed at mechanistic understanding of cardiovascular disease. The instrument will provide data individually tailored to these Aims. Preliminary studies have been performed using a comparable instrument located at a remote site, the Iowa City VA Medical Center. These studies have demonstrated the capability of the instrument to provide accurate reliable image data non-invasively. Unfortunately, the remote location of that instrument, and its use full time as a clinical imager, impose critical restraints on the number and complexity of experiments that can be performed. These studies have demonstrated the capability of the instrument to provide accurate reliable image data non-invasively. Unfortunately, the remote location of that experiment, and its use full time as a clinical imager, impose critical restraints on the number and complexity of experiments that can be performed. In pursuit of the Aims of the investigators, we request an instrument that will be devoted entirely to research in laboratory animals.