POST-PRANDIAL NUTRIENT PARTITIONING IN HUMANS

说明(改编自应用程序) 此应用程序的目的是确保部分工资支持的资金 让指定的私家侦探解除他的一些临床责任 目前提供工资的公司。这将为患者提供更多的时间 本提案中概述的定向研究和对博士后研究员的指导 在科罗拉多健康大学人类营养中心(CHN) 科学中心(UCHSC)。私家侦探很有能力担任这些角色 他在人类肥胖领域有临床研究的历史， 最近获得了用于人类营养研究的独立资金，并正在 目前担任CHN研究培训副主任 在詹姆斯·希尔博士的指导下。全科临床的出现 研究中心(GCRC)、临床营养研究单位(CNRU)和 CHN使UCHSC成为肥胖相关研究的一个令人兴奋的机构 吸引了一大批优秀的博士后研究员 是否需要[原文如此]职业中期的MD来帮助指导 装填。这一奖项将巩固候选人在重要时刻担任这一职位的能力 对他和CHN来说。这项拟议的研究检验了如下假设 与容易增加体重的人相比，瘦的人更 准确感知并在代谢和行为上对正能量做出反应 平衡。据推测，与减少肥胖相比，苗条的个人 将对一段时间的正能量平衡做出反应，以减少 葡萄糖氧化(胰岛素抵抗)，氧化增加 骨骼肌中的膳食脂肪，以及进食动力的降低。其结果是 这些燃料代谢的不同之处在于，苗条的人会更多地 有效地防御正脂肪平衡的状态 减少肥胖。为了测试这些想法，瘦身和减重的肥胖个人将 经过3天的过量喂养后进行研究。1.进行正血糖钳夹手术 为了检查胰岛素敏感性，2.将进行膳食研究，检查 试验餐中标记脂肪和碳水化合物的代谢去向，以及3. 饥饿感、饱腹感和适口性将在过程中和之后进行测量 高热量饮食。间接量热法、示踪剂氧化、肢体平衡和 建议对骨骼肌和脂肪组织进行采样，以提供更多 完整了解这两组的膳食相关营养代谢情况。这些 研究将提供对易导致体重回升的生物学的洞察 在减轻体重之后，将为未来的研究奠定基础 肥胖和肥胖前期患者存在的营养代谢异常 个人。

DESCRIPTION (adapted from the application) The purpose of this application is to secure funding for partial salary support for the named P.I. to relieve him from some of the clinical responsibilities that currently provide salary. This would allow more time to perform patient oriented research outlined in this proposal and mentoring post-doctoral fellows at the Center for Human Nutrition (CHN) at the University of Colorado Health Sciences Center (UCHSC). The P.I. is well positioned to serve these roles in that he has a history of clinical research in the area of human obesity, has recently received independent funding for human nutritional studies, and is currently serving as the Associate Director for Research Training at the CHN under the direction of Dr. James Hill. The presence of the General Clinical Research Center (GCRC), the Clinical Nutrition Research Unit (CNRU), and the CHN have made the UCHSC an exciting institution for obesity related research and has attracted a large number of excellent post-doctoral fellows but there is a need/opportunity for a mid [sic] career MD to help with the mentoring load. This award would solidify the candidate in this role at an important time for him and the CHN. The proposed research examines the hypothesis that as compared to individuals predisposed to weight gain, lean individuals more accurately sense and respond metabolically and behaviorally to positive energy balance. It is hypothesized that as compared to reduced obese, lean individuals will respond to a period of positive energy balance with a reduction [sic] the oxidation of glucose (insulin resistance), an increase in the oxidation of dietary fat by skeletal muscle, and a decreased drive to eat. The result of these differences in fuel metabolism are that lean individuals will more effectively defend against a state of positive fat balance as compared to reduced obese. To test these ideas lean and reduced obese individuals will be studied following 3-days of overfeeding. 1. Euglycemic clamps will be performed to examine insulin sensitivity, 2. meal studies will be performed examining the metabolic fate of labeled fat and carbohydrate included in a test meal, and 3. Hunger, satiety, and palatability will be measured during and following hypercaloric feeding. Indirect calorimetry, tracer oxidation, limb balance, and sampling of skeletal muscle and adipose tissue are proposed to give a more complete view of meal associated nutrient metabolism in these two groups. These studies will provide insight into the biology that predisposes to weight regain following weight reduction and will lay the groundwork for future studies of the abnormalities in nutrient metabolism that exist in obese and pre-obese individuals.