MBRS Program-University of Southern Colorado

描述（由申请人提供）：本提案要求支持一个新的SCORE计划，以取代现有的，传统的MBRS补助金在南科罗拉多大学（南加州大学）。参加这一新的SCORE申请的三个部门是生物学，化学和心理学的部门;这些部门中的每一个都提交了两个研究子项目。该计划的总体目标是提高机构的生物医学研究能力，吸引和招募代表性不足的少数民族参与生物医学研究企业。个人和项目目标支持这一使命。整体计划的具体目标如下：（1）提高生物学，化学和心理学系SCORE研究教师的研究竞争力或生产力;（2）增加校园内教师和学生，特别是少数民族，在生物医学研究中的参与。可衡量的目标和活动伴随着每一个目标。对于第一个具体目标，生产力将根据审阅的演示文稿，出版物，赠款提交和合作的数量来衡量。作为SCORE计划子项目的最低标准，已经制定了3篇出版物和10篇演讲的具体标准。对于第二个具体活动，SCORE的补充申请数量以及南加州大学教师参加资助讲习班、研讨会和教师研究圆桌会议的情况将用于评估目标的实现情况。一项评价计划和一个外部咨询委员会是这项赠款的重要组成部分，将加强拟议的活动，并将促进目标的完成。为了实现SCORE计划的总体目标，六个子项目和一个行政部分参与了这项赠款。六个研究项目包括两个在生物学，两个在化学，两个在心理学。其中一个生物学项目研究了pepsilen诱导的生殖毒性的机制。第二个生物学项目是一个生殖生理学项目，是对哺乳动物生殖逃逸事件的比较研究。化学项目是在生物化学和分析化学。生物化学项目通过使用标准化学方法和最近开发的原子力显微镜技术检查真菌细胞表面，为抗真菌剂的设计提供有价值的信息。该分析项目表征了可能用于分离复杂生物混合物和药物的新型二氧化硅表面。其中一个心理学项目研究了肽与酒精饱和度的相互作用，第二个项目研究了儿童阅读障碍与神经解剖学之间的关系。

DESCRIPTION (provided by applicant): This proposal requests support for a new SCORE Program to replace the existing, traditional MBRS grant at the University of Southern Colorado (USC). The three departments participating in this new SCORE application are the Departments of Biology, Chemistry, and Psychology; each of these departments has submitted two research subprojects. The overall goals of this program are to enhance institutional biomedical research capabilities and to attract and recruit underrepresented minority participation in the biomedical research enterprise. The individual and program goals support this mission. The specific goals of the overall program are as follows: (1) to increase the research competitiveness or productivity of SCORE research faculty in the Departments of Biology, Chemistry, and Psychology; and (2) to increase the participation of faculty and students on campus, especially minorities, in biomedical research. Measurable objectives and activities accompany each of these goals. For the first specific goal, productivity will be measured in terms of numbers of refereed presentations, publications, grant submissions, and collaborations. A specific standard of 3 publications and 10 presentations has been instituted as the minimum standard for the SCORE Program subprojects. For the second specific activity, the number of supplemental applications to SCORE and participation of USC faculty in grantmanship workshops, seminars, and faculty research roundtables will be used to assess the achievement of the goal. An evaluation plan and an external advisory committee are vital components of this grant and will enhance the activities proposed and will promote the completion of the goals. To achieve the overall SCORE program goals, six subprojects and an administrative component are participating in this grant. The six research projects include two in Biology, two in Chemistry, and two in Psychology. One of the biology projects examines the mechanisms of psoralen-induced reproductive toxicity. The second biology project, a reproductive physiology project, is a comparative study of events surrounding the zona escape in mammals. The Chemistry projects are in Biochemistry and Analytical Chemistry. The biochemistry project examines fungal cell surfaces by using standard chemical methods and the recently developed technique of atomic force microscopy, with the potential of providing valuable information for the design of antifungal agents. The analytical project characterizes novel silica surfaces that may be potentially used in separation of complex biological mixtures and pharmaceuticals. One of the Psychology projects examines the interactions of peptides with alcohol satiation and the second investigates the relationship between reading disabilities in children and neuroanatomy.