Exacerbation of Atherosclerosis

描述(由申请人提供)：动脉粥样硬化是主要的 与心肌和脑梗塞的发病机制有关，而NO 对于动脉粥样硬化，目前还没有有效的治疗方法。识别 黄斑狼疮的病因及发病机制的认识 动脉粥样硬化可能为制定有效的治疗策略提供信息 预防和/或控制心血管疾病的发病机制。两者都有 流行病学调查和动物模型研究将C. 肺炎从感染到动脉粥样硬化。本提案的目标 进一步评估肺炎衣原体感染在动脉粥样硬化中的作用 在小鼠模型系统中，并使用这个动物系统来理解 肺炎衣原体动脉粥样硬化形成机制的研究 炎症反应假说。具体地说，两种炎症性疾病的作用 肺炎衣原体急性加重期的应答和脂蛋白氧化 将对动脉粥样硬化进行评估。这些研究可能会提供必要的 关于设计有效的预防和控制C. 肺炎--加重动脉粥样硬化。

DESCRIPTION (provided by the applicant): Atherosclerosis is the principal contributor to the pathogenesis of myocardial and cerebral infarction, and no effective treatment is yet available for atherosclerosis. Identifying the etiological causes and understanding the pathogenic mechanisms of atherosclerosis may provide information for developing efficient strategies for preventing and/or controlling cardiovascular disease pathogenesis. Both epidemiological investigations and animal model studies have linked C. pneumoniae infection to atherosclerosis. The objectives of the present proposal are to further evaluate the role of C. pneumoniae infection in atherosclerosis in a mouse model system and to use this animal system to understand the mechanisms of C. pneumoniae atherogenesis by testing an infection / inflammatory response hypothesis. Specifically, the roles of both inflammatory responses and lipoprotein oxidation in C. pneumoniae exacerbation of atherosclerosis will be evaluated. These studies may provide the essential information on designing effective approaches for preventing and controlling C. pneumoniae-exacerbated atherosclerosis.