Training in Drug Abuse Related Research.

描述（由申请人提供）： 该培训计划的目标是为有前途的研究生和博士后研究员在药物滥用研究方面的成功职业做好准备。我们将提供基础广泛的培训，在药物滥用研究的现代概念，特别强调：（一）参与对药物的反应受体的细胞和分子研究（二）与这些受体相互作用的配体的发展作为药物滥用的潜在药物疗法和（三）神经艾滋病的细胞和分子方面。培训教师的统一重点是我们在分子水平上了解与药物滥用有关的基本机制的兴趣。该培训计划为几个不同部门的教师提供了正式的框架，这些部门在神经科学和分子机制方面具有共同和重叠的兴趣。培训教师的重点相互补充，重点是建立在药物滥用领域的长期优势，在受体相互作用和反应，神经可塑性和疾病（neuroAIDS，衰老和神经创伤）的分子方面的现有专业知识和有针对性的治疗剂的开发。因此，该计划将提供对药物滥用如何在大分子水平上影响细胞功能以及这种成瘾性转化如何影响健康的基本理解。学员将从教师谁利用国家的最先进的方法来探索药物滥用研究中的关键问题广泛学习。国家显然需要培训药物滥用研究方面的新调查人员，采用现代方法对这一领域今后的进展至关重要。只有我们更好地了解管制药物滥用的基本机制并应用这些知识，我们才能在解决药物滥用问题方面取得进展。该方案的一个独特方面是其受训人员与药物滥用心理和行为方面培训方案的受训人员之间的互动。因此，我们的学员将有分子，细胞，心理和行为药物滥用研究的广泛知识。这笔培训赠款将大大加强我们吸引和培训研究生和博士后研究员以应付药物滥用领域的挑战的能力。

DESCRIPTION (provided by applicant): The goal of this training program is to prepare promising graduate students and postdoctoral fellows for successful careers in drug abuse research. We will provide broad-based training in modern concepts of drug abuse research with a special emphasis on: (i) cellular and molecular studies of receptors involved in the response to drugs (ii) development of ligands which interact with these receptors as potential pharmacotherapies for drug abuse and (iii) cellular and molecular aspects of neuroAIDS. The unifying focus of the training faculty is our interest in understanding basic mechanisms related to drug abuse at the molecular level. This training program provides the formal framework for faculty in several different departments who share common and overlapping interests in neuroscience and molecular mechanisms. The emphasis of the training faculty complement each other with a focus on building upon long-term strengths in the drug abuse field with existing expertise in molecular aspects of receptor interaction and response, neuroplasticity and disease (neuroAIDS, aging and neurotrama) and the development of targeted therapeutic agents. Thus, the program will provide a fundamental understanding of how drugs of abuse affect cell function at the macromolecular level and how this addictive transformation affects health. Trainees will learn from faculty who utilize a broad spectrum of state-of-the-art methodological approaches to probe critical questions in drug abuse research. The national need for training new investigators in drug abuse research is clear and the introduction of modern methodologies is crucial for future advances in this area. Only if we better understand the basic mechanisms that regulate drug abuse and apply this knowledge, will we make progress in solving the problems of drug abuse. A unique aspect of this program is the interaction of its trainees with those from a training program in the psychological and behavioral aspects of drug abuse. Thus our trainees will have a broad based knowledge of both molecular, cellular, psychological and behavioral drug abuse research. Our ability to attract and train graduate students and postdoctoral fellows to meet the challenges in the area of drug abuse will be greatly enhanced by this training grant.