Center for Biomedical Research Excellence in the Molecular Basis of Human Disease

描述(由申请者提供)：这项建议建立在前一次资助期间取得的成就的基础上，并请求Cobre(人类疾病分子基础生物医学研究卓越中心)的继续支持。在四年期间，科布雷助学金一直很活跃，来自9个不同部门的22名初级教员得到了指导，其中8人获得了NIH R01资金，另外4人获得了其他形式的校外资金。参加中心活动的还有11名教职员工、11名博士后/研究助理和9名研究生。该中心成员发表了175多篇研究论文，并在科学会议上发表了38次演讲。在科布雷的任期内，科布雷所在的分子和细胞生物化学系在NIH公立医学院的排名中从第28位上升到第12位，在所有医学院中的排名从第26位上升到第26位。这是通过增加5,148,302美元的NIH赠款来实现的，其中不包括科布雷基金。分子医学中心成立于2007年，这是COBRE第一阶段(2004年8月至2009年7月)取得成就的直接结果。 在Cobre的第二阶段，我们建议建立一个国家和国际公认的 将继续有效竞争校外研究资金的研究中心。为了实现这一目标，我们建议：1)扩大我们的调查人员的临界数量，包括指导另外5名 正在研究人类疾病分子基础的有前途的初级研究人员。这将包括一名有针对性的大学新招聘人员。我们将通过促进与临床教师的互动，增加将他们的研究转化为患者的机会。我们将继续专注于癌症、糖尿病和神经疾病；ii)我们将扩大并继续发展我们在蛋白质组学、化学、显微镜、蛋白质表征和小鼠基因鉴定方面的核心设施。三)继续支持试点研究项目。这是一种非常有效的方式，可以加强相当数量的初级教员的研究；iv)通过提交计划项目赠款和多元PI赠款，促进可持续中心的发展。我们将提供人力资源和试点资金，以加强这些活动。 公共卫生相关性(由申请者提供)：通过资助有前途的初级教员和提供最先进的研究核心来提高肯塔基大学初级教员的竞争力。

DESCRIPTION (provided by applicant): This proposal builds upon the accomplishments made during the previous funding period and requests continuing support of COBRE, the Center of Biomedical Research Excellence in the Molecular Basis of Human Disease. During the four year period this COBRE grant has been active, 22 junior faculty from 9 different departments were mentored of which 8 received NIH R01 funding and an additional 4 received Other forms of extramural funding. Participating in the activities of the Center has been an additional 11 faculty, 11 postdoctoral/research associates and 9 graduate students. The members of the Center published more than 175 research papers, and made 38 presentations at scientific meetings. The Department of Molecular and Cellular Biochemistry, in which the COBRE is housed, rose from 28th to 12th in NIH rankings in terms of Public Medical Schools, and 26th in terms of all Medical Schools during the tenure of the COBRE. This was accomplished by an increase in $5,148,302 of NIH grant dollars excluding the COBRE funds. The Center for Molecular Medicine was formed in 2007 as a direct consequence of the accomplishments made during the first phase of the COBRE (Aug 2004- July 2009). In the second phase of this COBRE we propose to establish a nationally and internationally recognized research center that will continue to compete effectively for extramural research funding. To accomplish this we propose i) to expand our critical mass of investigators including the mentoring of an additional 5 promising junior investigators who are studying the molecular basis of human disease. This will include a targeted new recruit to the University. We will enhance the opportunity to translate their research to patients by facilitating interactions with clinical faculty. We will continue with the major focus in cancer, diabetes, and neurological diseases, ii) We will expand and continue to develop our core facilities in Proteomics, Chemistry, Microscopy, Protein characterization, and Mouse Genotyping. iii) We will continue to support pilot research projects. This has been a highly effective way to enhance the research of a rather significant number of junior faculty; iv) facilitate the development of a sustainable center through the submission of program project grants and multi-PI grants. We will provide staff resource and pilot funding to enhance these activities. PUBLIC HEALTH RELEVANCE (provided by applicant): To enhance the competitiveness of junior faculty at the University of Kentucky through the funding of promising junior faculty and providing state-of-the-art research cores.