Training--Signal Transduction and Cellular Endocrinology

描述（由申请人提供）：此竞争性续期申请要求为继续在芝加哥伊利诺伊大学的信号转导和细胞内分泌学现有培训计划提供资金。该博士前和博士后培训计划提供信号转导，基因转录/翻译和细胞内分泌学相关领域的跨学科培训，重点是抑制信号和调节细胞，组织和有机体对其外部环境的反应的细胞和分子机制。培训计划的持续目标是培养独立的基础科学和临床研究人员，并在信号转导，细胞内分泌学和基因转录/翻译的广泛方面培养博士生。该培训计划的一个基本主题是协调和促进博士前和博士后研究人员之间的互动，这些研究人员正在使用不同的实验系统和方法来理解组织各级的信号转导机制，包括分子，细胞和综合生物学。该培训计划跨越学科和部门的界限，利用来自六个基础科学部门的三十三名教师的专业知识（解剖学和细胞生物学，生物化学和分子生物学，分子遗传学，微生物学和免疫学，药理学，生理学和生物物理学）和三个临床部分内科（血液肿瘤学、内分泌代谢学、风湿病学），并提供机会，在信号转导和相关领域的广泛问题，使用广泛的分子，生物化学，生理学，遗传学和结构生物学方法。信号传导，细胞周期调控，基因转录，癌症生物学，发育生物学以及内分泌和神经体液信号传导等领域代表了UIC研究人员的主要优势，并且已经从所有这些群体中抽取了导师。博士前培训包括理论，技术和研究观点，通过教学课程，研究报告，研讨会，非正式的互动，研究轮换和年度务虚会。信号转导，内分泌学课程，以及分子和细胞生物学，生物化学，遗传学，结构生物学，生理学和药理学，科学交流和负责任的研究行为的核心课程为密集的研究环境提供了基础。教师培训师的研究兴趣范围从神经体液信号，膜受体和转导机制，第二信使，细胞周期控制，转录/翻译调控和结构生物学。博士后研究员接受两三年的培训，根据他们的研究兴趣，背景和具体课程需求量身定制。所有学员都参加了信号传导和其他研讨会，以及该计划支持的年度芝加哥大都市区信号传导研讨会。该培训计划强调当代信号转导研究的跨学科性质，培养独立和创造性思维的环境。我们预计，该计划将最终有助于产生优秀的独立调查人员谁将在信号转导的广泛领域作出重大贡献，谁将最终服务于丰富科学进步和社区。

DESCRIPTION (provided by applicant):This competitive renewal application requests funding for the continuation of the existing Training Program in Signal Transduction and Cellular Endocrinology at the University of Illinois at Chicago. This predoctoral and postdoctoral training program provides interdisciplinary training in the related fields of signal transduction, gene transcription/translation, and cellular endocrinology, with emphasis on both cellular and molecular mechanisms that transduce signals and regulate cell, tissue and organismal responses to their external environment. The continuing goal of the training program is to develop independent basic science and clinical investigators, and to train doctoral candidates in broad aspects of signal transduction, cellular endocrinology, and gene transcription/translation. An underlying theme in this training program has been the coordination and promotion of interactions between pre-and post-doctoral researchers who are using different experimental systems and approaches toward understanding signal transduction mechanisms at various levels of organization including molecular, cellular and integrative biology. The training program crosses both disciplinary and departmental lines, drawing upon the expertise of thirty-three faculty from six basic science departments (anatomy and cell biology, biochemistry and molecular biology, molecular genetics, microbiology and immunology, pharmacology, physiology and biophysics) and three clinical sections (hematology-oncology, endocrinology and metabolism, rheumatology) in the Department of Medicine, and offering opportunities in a wide range of problems in signal transduction and allied areas using a broad spectrum of molecular, biochemical, physiologic, genetic, and structural biology approaches. The areas of signaling, cell cycle regulation, gene transcription, cancer biology, developmental biology, and endocrine and neurohumoral signaling represent major strengths of researchers at UIC and preceptors have been drawn from all these groups. Predoctoral training includes theory, techniques and research perspectives through didactic courses, research presentations, seminars, informal interactions, research rotations, and a yearly retreat. Courses in signal transduction, endocrinology, and a core curriculum in molecular and cellular biology, biochemistry, genetics, structural biology, physiology, and pharmacology, scientific communication, and responsible conduct of research provide the foundation for an intensive research environment. Faculty trainers' research interests range from neurohumoral signaling, membrane receptors and transduction mechanisms, to second messengers, cell cycle control, transcriptional/translational regulation, and structural biology. Postdoctoral fellows are trained in two or three year programs tailored to their research interests, background and specific course needs. All trainees are participants in Signal Transduction and other seminars, and an annual Chicago metropolitan area Signal Transduction Symposium which the program supports. The training program emphasizes the interdisciplinary nature of contemporary research in signal transduction in an environment that fosters independent and creative thinking. We anticipate that the program will ultimately contribute to the generation of outstanding independent investigators who will make significant contributions in the broad area of signal transduction, and who will ultimately serve to enrich scientific progress and community.