OSTEOPOROSIS PREVENTION IN SEDENTARY ADOLESCENT FEMALES

描述(改编自调查人员的摘要)：这一目标 研究是为了实施一种新的行为程序，旨在增加 锻炼身体，增强骨骼矿化。这项研究的重点是 久坐不动的青春期女性，这是一个特别容易患癌症的人群 晚年出现骨质疏松症。调查人员推测， 干预将增加体力活动，这些活动的增加 将与特定心理社会特征的变化有关，以及 它们将导致骨形成和骨密度的增加 超过10个月。这项拟议的研究旨在：(1)检验干预 旨在增加女青少年的体力活动；(2)评估 干预的一个组成部分的有效性，包括基于互联网的 与励志榜样故事相联系的锻炼日记；(3)评估 可能易感的特定心理社会特征的各自作用 采用和保持体力活动；(4)确定是否 随着时间的推移，心理社会特征的积极变化与 增加对体育活动的参与；以及(5)检验以下假设 增加体力活动可促进骨骼矿化。 久坐的青春期女性将被分配到全面干预(n=100)， 改良干预组(n=100)或对照组(n=100)。全 参与者将每天接受钙质补充。骨的形成将是 在基线(DEXA)、5周和5个月进行评估。(血清和尿液测量)，以及 10个小时。(DXA)。心理社会特征与体力活动参与 将在所有四个间隔进行测量。

Description (adapted from the investigator's abstract): The goal of this research is to implement a novel behavioral program designed to increase physical activity and enhance bone mineralization. The study focuses on sedentary adolescent females, a population at particularly high risk for developing osteoporosis later in life. The investigators hypothesize that the intervention will increase physical activity, that these increases in activity will be associated with changes in specific psychosocial characteristics, and that they will lead to increases in bone formation and bone mineral density over 10 months. The proposed research intends to: (1) test the intervention designed to increase female adolescents' physical activity; (2) evaluate the efficacy of one component of the intervention consisting of an Internet-based exercise diary linked with motivational role model stories; (3) evaluate the respective roles of specific psychosocial characteristics that may predispose toward the adoption and maintenance of physical activity; (4) determine whether positive changes in psychosocial characteristics over time are associated with increased participation in physical activity; and (5) test the hypothesis that increased physical activity enhances bone mineralization. Sedentary adolescent females will be assigned to full intervention (n=100), modified intervention (n=100), or comparison group (n=100) for 10 months. All participants will receive daily calcium supplementation. Bone formation will be assessed at baseline (DEXA), 5 wks and 5 mo. (serum and urinary measures), and 10 mo. (DEXA). Psychosocial characteristics and physical activity participation will be measure at all four intervals.