Three-Dimensional Ocular Imaging Using Ultrasound

描述（由申请人提供）：本项目的目标是开发能够提供眼前节详细图像的超声成像阵列。该阵列将用于创建用于确定人工透镜植入物尺寸和治疗病理状况的解剖图像，以及屈光手术中使用的厚度测量和地形图。 在第一阶段，我们制作了原型传感器元件，并证明了该元件具有足够的灵敏度来检测前，后角膜表面和鲍曼氏膜在离体牛眼。 在第二阶段，我们计划制作一个完整的二维成像阵列，并测试阵列上的声学幻影，兔眼，人眼提供的眼库。动物和人类眼睛的测试将由我们在康奈尔大学威尔医学院的临床合作者进行。我们还将与商业化合作伙伴合作，将我们的阵列集成到他们的眼部成像系统中。

DESCRIPTION (provided by applicant): The goal of this project is development of an ultrasonic imaging array capable of providing detailed images of the anterior segment of the eye. The array will be used to create anatomic images used for sizing of intraocular lens implants and treating pathological conditions, as well as pachymetric and topographic maps used in refractive surgery. During Phase I, we fabricated prototype transducer elements and demonstrated that the elements had sufficient sensitivity to detect the anterior and posterior corneal surfaces and Bowman's membrane in an ex vivo bovine eye. In Phase II, we plan to fabricate a complete two-dimensional imaging array and test the array on acoustic phantoms, rabbit eyes, and human eyes provided by the eye bank. Testing on animal and human eyes will be conducted by our clinical collaborators at the Weill Medical College of Cornell University. We will also work with our commercialization partner to integrate our array into their ocular imaging system.