Expansion, Differentiation and Functional Analysis of In Vitro Derived Pdx1+ Pancreatic Progenitors
Expansion, Differentiation and Functional Analysis of In Vitro Derived Pdx1+ Pancreatic Progenitors
批准号:
nhmrc : 519502
负责人:
Prof Andrew Elefanty
金额:
$36.01万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
1型糖尿病是一种身体免疫系统破坏胰腺内产生胰岛素的细胞而引起的疾病。最近的研究表明,通过移植来自已故供者的细胞来替代缺失的β细胞,可以恢复正常的血糖控制。然而,对移植材料的需求大于供应。本应用程序中描述的工作旨在确定如何在实验室中从胚胎干细胞中获得产生胰岛素的β细胞。
英文摘要
Type 1 diabetes is a condition that arises when the body's immune system destroys insulin-producing beta cells within the pancreas. Recent studies have shown that normal glucose control can be restored by replacing the missing beta cells by transplantation of cells from deceased donors. However, the demand for transplant material outweighs supply. The work described in this application seeks to define how insulin-producing beta cells can be derived in the laboratory from embryonic stem cells .
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会议论文
Transcriptional regulation of definitive hematopoietic development in humans
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批准号:nhmrc : GNT1129861
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项目类别:Project Grants
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资助金额:$80.0万
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财政年份:2017
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负责人:Prof Andrew Elefanty
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依托单位:
Generating haematopoietic stem cells from human pluripotent stem cells
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批准号:nhmrc : 1129125
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项目类别:Project Grants
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资助金额:$59.5万
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财政年份:2017
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负责人:Prof Andrew Elefanty
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依托单位:
Haematopoietic stem cells from human pluripotent stem cells: the future of bone marrow transplantation
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批准号:nhmrc : GNT1117596
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项目类别:Research Fellowships
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资助金额:$76.38万
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财政年份:2017
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负责人:Prof Andrew Elefanty
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依托单位:
Haematopoietic stem cells from human pluripotent stem cells: the future of bone marrow transplantation
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批准号:nhmrc : 1117596
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项目类别:Research Fellowships
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资助金额:$52.22万
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财政年份:2017
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负责人:Prof Andrew Elefanty
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依托单位:
Transcriptional regulation of definitive hematopoietic development in humans
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批准号:nhmrc : 1129861
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项目类别:Project Grants
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资助金额:$54.63万
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财政年份:2017
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负责人:Prof Andrew Elefanty
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依托单位:
Generating haematopoietic stem cells from human pluripotent stem cells
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批准号:nhmrc : GNT1129125
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项目类别:Project Grants
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资助金额:$87.22万
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财政年份:2017
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负责人:Prof Andrew Elefanty
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依托单位:
A suite of engineered human pluripotent stem cell lines to facilitate the generation of hematopoietic stem cells
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批准号:nhmrc : GNT1099414
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项目类别:International Collaborations
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资助金额:$88.12万
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财政年份:2015
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负责人:Prof Andrew Elefanty
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依托单位:
A suite of engineered human pluripotent stem cell lines to facilitate the generation of hematopoietic stem cells
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批准号:nhmrc : 1099414
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项目类别:Targeted Calls
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资助金额:$59.52万
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财政年份:2015
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负责人:Prof Andrew Elefanty
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依托单位:
Control of human ? cell differentiation and function
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批准号:nhmrc : 1062268
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项目类别:Project Grants
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资助金额:$41.14万
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财政年份:2014
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负责人:Prof Andrew Elefanty
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依托单位:
Characterization of HOXA-expressing human haematopoietic cells generated from embryonic stem cells
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批准号:nhmrc : 1068866
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项目类别:Project Grants
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资助金额:$41.51万
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财政年份:2014
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负责人:Prof Andrew Elefanty
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依托单位:
Endothelial development from pluripotent stem cells as a means to study pathology in Pulmonary Artery Hypertension
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批准号:nhmrc : 1051339
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项目类别:Project Grants
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资助金额:$40.9万
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财政年份:2013
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负责人:Prof Andrew Elefanty
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依托单位:
NHMRC Research Fellowship. Genetic modification and differentiation of human pluripotent stem cells: creating tools for regenerative medicine and models for disease
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批准号:nhmrc : 1002154
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项目类别:Research Fellowships
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资助金额:$50.5万
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财政年份:2011
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负责人:Prof Andrew Elefanty
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依托单位:
Characterisation of human embryonic stem cell differentiation to haematopoietic progenitors and stem cells
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批准号:nhmrc : 1009540
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项目类别:NHMRC Project Grants
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资助金额:$42.6万
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财政年份:2011
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负责人:Prof Andrew Elefanty
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依托单位:
Derivation of Pancreatic Beta cells from embryonic stem cells
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批准号:nhmrc : 465199
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项目类别:NHMRC Strategic Awards
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资助金额:$197.91万
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财政年份:2007
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负责人:Prof Andrew Elefanty
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依托单位:
Research Fellowship - Grant ID:334100
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批准号:nhmrc : 334100
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项目类别:NHMRC Research Fellowships
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资助金额:$43.5万
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财政年份:2005
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负责人:Prof Andrew Elefanty
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依托单位:
Creating b-cells to cure type 1 diabetes
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批准号:nhmrc : 219172
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项目类别:NHMRC Strategic Awards
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资助金额:$284.06万
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财政年份:2002
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负责人:Prof Andrew Elefanty
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依托单位:
Haemopoiesis and embryonic development
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批准号:nhmrc : 219329
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项目类别:NHMRC Block Funding
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资助金额:$22.02万
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财政年份:2002
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负责人:Prof Andrew Elefanty
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 215219
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项目类别:NHMRC Research Fellowships
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资助金额:$19.7万
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财政年份:2002
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负责人:Prof Andrew Elefanty
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依托单位:
海外基金