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Expansion, Differentiation and Functional Analysis of In Vitro Derived Pdx1+ Pancreatic Progenitors

Expansion, Differentiation and Functional Analysis of In Vitro Derived Pdx1+ Pancreatic Progenitors
体外衍生的 Pdx1 胰腺祖细胞的扩增、分化和功能分析
批准号:
nhmrc : 519502
负责人:
Prof Andrew Elefanty
金额:
$36.01万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31

项目摘要

项目成果

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中文摘要
翻译
1型糖尿病是一种身体免疫系统破坏胰腺内产生胰岛素的细胞而引起的疾病。最近的研究表明,通过移植来自已故供者的细胞来替代缺失的β细胞,可以恢复正常的血糖控制。然而,对移植材料的需求大于供应。本应用程序中描述的工作旨在确定如何在实验室中从胚胎干细胞中获得产生胰岛素的β细胞。
英文摘要
Type 1 diabetes is a condition that arises when the body's immune system destroys insulin-producing beta cells within the pancreas. Recent studies have shown that normal glucose control can be restored by replacing the missing beta cells by transplantation of cells from deceased donors. However, the demand for transplant material outweighs supply. The work described in this application seeks to define how insulin-producing beta cells can be derived in the laboratory from embryonic stem cells .
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Transcriptional regulation of definitive hematopoietic development in humans
  • 批准号:
    nhmrc : GNT1129861
  • 项目类别:
    Project Grants
  • 资助金额:
    $80.0万
  • 财政年份:
    2017
  • 负责人:
    Prof Andrew Elefanty
  • 依托单位:
Generating haematopoietic stem cells from human pluripotent stem cells
  • 批准号:
    nhmrc : 1129125
  • 项目类别:
    Project Grants
  • 资助金额:
    $59.5万
  • 财政年份:
    2017
  • 负责人:
    Prof Andrew Elefanty
  • 依托单位:
Haematopoietic stem cells from human pluripotent stem cells: the future of bone marrow transplantation
  • 批准号:
    nhmrc : GNT1117596
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $76.38万
  • 财政年份:
    2017
  • 负责人:
    Prof Andrew Elefanty
  • 依托单位:
Haematopoietic stem cells from human pluripotent stem cells: the future of bone marrow transplantation
  • 批准号:
    nhmrc : 1117596
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $52.22万
  • 财政年份:
    2017
  • 负责人:
    Prof Andrew Elefanty
  • 依托单位:
海外基金