Personal Dosimeter for OPs Using Nano-structured Surface

描述(由申请人提供)：该项目的长期目标是开发一种用于测量累积接触有机磷(OP)杀虫剂的被动监测仪。这款监视器是基于对液晶锚定到由金属离子功能化的表面的创新开发。在第一阶段，我们演示了选择选择性地结合OP的金属组合的能力，以及设计多个金属阵列来识别单个OP的能力。我们还展示了使用这项新技术来测量三周内商业配方OP杀虫剂的ppb浓度的累积暴露。我们创建的表面不受湿度的影响，并且表现出稳定性。这些数据有力地支持了Platypus TM技术作为小型、廉价、坚固耐用的被动监测仪的可行性，适用于测量儿童和成人的累积农药暴露。在第二阶段，我们将检查潜在干扰化合物的影响，我们将根据实验室和现场条件下的标准采样方法校准我们的原型监视器，我们将优化材料、外壳和读出方法的选择，以纳入现场原型监视器的设计。该样机将在现场条件下进行测试，以确定精密度和准确度。

DESCRIPTION (provided by applicant): The long-term goal of this project is to develop a passive monitor for measurement of cumulative exposure to organophosphate (OP) pesticides. This monitor is based on the innovative exploitation of the anchoring of liquid crystals to a surface functionalized with metal ions. In Phase 1, we demonstrated the ability to select combinations of metals that would selectively bind OPs and to design multi-arrays of metals to identify individual OPs. We also demonstrated the use of this new technology to measure cumulative exposure to ppb concentrations of commercial formulations of OP pesticides over a three-week period. The surfaces we created were not affected by humidity and exhibited stability. These data strongly support the feasibility of Platypus TM technology as the basis of small, inexpensive, rugged passive monitors suitable for measuring cumulative pesticide exposure in children and adults. In Phase 2, we will examine the effects of potential interfering compounds, we will calibrate our prototype monitors against standard sampling methods under laboratory and field conditions and we will optimize choice of materials, housing, and read out methods to incorporate in the design of a field prototype monitor. This prototype will be tested under field conditions to determine precision and accuracy.