Training Curriculum in Patient Oriented Research

描述（由申请人提供）： 生产临床研究的领导者是UT西南的一个主要目标。在过去的四年里，我们的K30培训计划在以患者为导向的研究（POR）已经招收了130多名学员，其中65人仍然活跃，34人已经提交了超过120笔赠款，其中43%已获得资助。另外还招聘了30名全职教师导师，其中17名是基础科学家。在这个竞争性的续约申请中，我们打算通过实现以下具体目标来接近我们的目标：1）提供深入的培训和实践经验，以促进独立的发展（RO-1资助）-研究人员：a）通过遗传学和蛋白质组学，临床药理学和药物开发，赠款写作，转化研究和管理方面的新互动课程扩展课程; B）由基础和临床研究人员对受训人员进行双重指导，以加强科学严谨性和转化研究; c）在指导的POR项目中提供实践经验; d）开始撰写和提交职业发展奖申请的过程。此外，我们扩大的K30课程将作为POR硕士学位课程的模板，支持导师作为学术活动，并促进进一步采购T32，K12，K24和F32赠款; 2）到2010年将培训计划发展成为一个自我维持（K30独立）计划。为了实现这一目标，我们将整合行政，指导和教学培训组件到生物统计学和临床科学在UT西南部，一个核心的临床研究教育，培训和服务设施的临床研究人员，将成为一个学术部门在2004年的新部门。我们新的扩展课程是全面的，基础广泛的，并利用UT西南最好的基础和临床科学资源。继续支持这笔赠款是至关重要的UT西南的使命，并将确保我们的培训计划在POR继续是非常成功的，并在轨道上产生领导人在POR。

DESCRIPTION (provided by applicant): Producing leaders in clinical research is a major goal at UT Southwestern. Over the past four years our K30 training program in patient-oriented research (POR) has enrolled over 130 trainees, 65 of whom remain active, and 34 have submitted over 120 grants of which 43% have been funded. Thirty additional full-time faculty mentors have been recruited among whom 17 are basic scientists. In this competitive renewal application we intend to move closer to our goal by fulfilling the following Specific aims: 1) Provide in-depth training and practical experience to foster development of independent (RO-1 funded) -investigators by: a) expanding the curriculum with new interactive courses in genetics and proteomics, clinical pharmacology and drug development, grant writing, translational research, and management; b) creation of dual mentorship of trainees by basic and clinical researchers to enhance scientific rigor and translational research; c) providing practical experience in a mentored POR project; d) beginning the process of writing and submitting a career development award application. In addition, our expanded K30 curriculum will serve as a template for a Masters Degree program in POR, support mentorship as an academic activity and catalyze further procurement of T32, K12, K24 and F32 grants; and 2) Evolve the training program into a self-sustaining (K30-independent) program by the year 2010. To accomplish this aim we will integrate administrative, mentoring and didactic training components into the new Department of Biostatistics and Clinical Science at UT Southwestern, a core clinical research education, training and service facility for Clinical researchers that will become an Academic department in 2004. Our new expanded curriculum is comprehensive, broad-based and takes advantage of the best basic and clinical science resources at UT Southwestern. Continuing support of this grant is critical for UT Southwestern's mission and will ensure that our training program in POR continues to be highly successful and on track to produce leaders in POR.