Brain Tumor SPORE Grant

描述(由申请人提供)： 这份申请代表了来自 加州大学旧金山分校癌症中心神经肿瘤学计划将他们的知识和专业知识应用于 翻译研究的重点是脑瘤。该提案的核心是四个转化性研究项目，每个项目都由应用和基础研究人员对推动，每个项目都旨在创造可能对治疗人类脑瘤有用的新工具和疗法。第一个项目的重点是使用人口科学来寻找影响胶质瘤患者生存的重要因素。项目二侧重于使用复杂的光谱技术来改进肿瘤的诊断和手术切除。项目三侧重于脂质体药物传递的发展，以改善胶质瘤的治疗，而项目四旨在表征信号转导级联作为指导胶质瘤治疗的手段。该提案还包括职业发展研究方案、发展研究方案的支持机制，以及将支持拟议工作的所有方面的2个核心。每个项目都借鉴了脑瘤领域研究人员的丰富经验，以及加州大学旧金山分校神经外科和加州大学脑肿瘤研究中心在翻译研究方面的悠久历史。这些项目将通过合作得到额外的加强 加州大学旧金山分校癌症中心的研究人员和其他科学家之间的合作，以及(特别是在项目三的情况下)与参与现有加州大学旧金山分校乳腺肿瘤孢子的科学家之间的合作。最后，作为美国领先的脑瘤临床试验中心，神经外科已经建立的基础设施将使重要科学突破的快速临床转化成为可能。加州大学旧金山分校的脑瘤孢子由Mitchel Berger医学博士领导，Mitchel Berger是全国公认的神经外科和转化性脑瘤研究的领导者。这项提议的临床合作者是迈克尔·普拉多斯，医学博士。普拉多斯博士是北美脑瘤联合会的负责人，也是儿科脑瘤联合会的首席研究员。他是临床试验开发和实施方面公认的领导者，非常适合将我们的发现带到临床上。临床专业知识以及加州大学旧金山分校强大的实验室研究氛围表明，拟议中的工作将导致脑瘤治疗方面的重大进展。

DESCRIPTION (provided by applicant): This application represents the efforts of interdisciplinary teams of investigators from the Neuro-Oncology Program of the UCSF Cancer Center to apply their knowledge and expertise to translational research focused on brain tumors. The heart of the proposal is four translational research projects, each driven by pairs of applied and basic researchers, and each intended to create novel tools and therapies potentially useful in the treatment of human brain tumors. Project One focuses on the use of population science to find factors important in glioma patient survival. Project Two focuses on the use of sophisticated spectroscopic techniques to improve diagnosis and surgical resection of tumors. Project Three focuses on the development of liposomal drug delivery to improve the therapy of gliomas, while Project Four intends to characterize signal transduction cascades as a means of guiding glioma therapy. The proposal also includes support mechanisms for Career Development Research Programs, Developmental Research Programs, and 2 Cores that will support all aspects of the work proposed. Each project draws on the extensive experience of the investigators in the brain tumor field and on the long history of the UCSF Department of Neurosurgery and the UCSF Brain Tumor Research Center in translational research. The projects will be additionally strengthened by collaborations between researchers and other scientists in the UCSF Cancer Center, and (particularly in the case of Project Three), with scientists involved with the existing UCSF Breast Tumor SPORE. Finally, as a leading center of brain tumor clinical trials in America, an infrastructure already in place in the Department of Neurosurgery will allow the rapid clinical translation of important scientific breakthroughs. The UCSF Brain Tumor SPORE is led by Mitchel Berger, MD, a nationally recognized leader in neurosurgery and translational brain tumor research. The clinical Co-PI of this proposal is Michael Prados, MD. Dr. Prados is head of the North American Brain Tumor Consortium, and a Principal Investigator of the Pediatric Brain Tumor Consortium. He is a recognized leader in the development and implementation of clinical trials, and is ideally suited to carry our findings to the clinic. The clinical expertise, along with the strong laboratory-based research climate at UCSF, suggest that the work proposed will lead to significant progress in the treatment of brain tumors.