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Measurement of HIV Neutralization

Measurement of HIV Neutralization
HIV 中和的测量
批准号：
6987252
负责人：
John R Mascola
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6987252
关键词：
AIDS education /preventionAIDS vaccinesantigen antibody reactionbioassayflow cytometryhuman immunodeficiency virus 1human tissuemethod developmentmonoclonal antibodyneutralizing antibodytissue /cell culturevaccine developmentvirus antigen

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中文摘要
翻译
目前对新型人类免疫缺陷病毒1型（HIV-1）疫苗免疫原的设计进行了深入的研究，这些免疫原可以引发有效的中和抗体。比较和优化这些策略的先决条件是精确测量中和抗体反应的能力。为此，我们试图开发一种直接定量外周血单个核细胞（PBMC）单轮HIV-1感染的检测方法。该分析的精确性和可重复性将有助于测量HIV-1中和，特别是由新的候选疫苗产生的逐渐改善的中和抗体反应。
英文摘要
There is currently intensive research on the design of novel human immunodeficiency virus type 1 (HIV-1) vaccine immunogens that can elicit potent neutralizing antibodies. A prerequisite for comparing and optimizing these strategies is the ability to precisely measure neutralizing antibody responses. To this end, we sought to develop an assay that directly quantifies single-round HIV-1 infection of peripheral blood mononuclear cells (PBMC). The precision and reproducibility of this assay will facilitate the measurement of HIV-1 neutralization, particularly incrementally improved neutralizing antibody responses generated by new candidate vaccines.
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会议论文
PASSIVE ANTIBODY PROTECTION IN SHIV CHALLENGE MODEL
PASSIVE ANTIBODY PROTECTION IN SHIV CHALLENGE MODEL
PASSIVE ANTIBODY PROTECTION IN SHIV CHALLENGE MODEL
Immunogenicity Studies of HIV-1 immunogens
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